Treatment of chronic heart failure guided by plasma natriuretic peptide levels

机译：血浆利钠肽水平引导的慢性心力衰竭治疗

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The hypothesis under which treatment of patients with chronic heart failure guided by monitoring natriuretic peptides levels could have better clinical outcomes than conventional therapy guided by the patients' clinical status (symptoms) is an attractive one. This hypothesis has been tested in several randomized clinical trials (STARS-BNP, TIME-CHF, PRIMA) with controversial results. In our OPTIMA clinical trial, 52 patients with chronic heart failure were randomized to either brain natriuretic peptide (BNP)-guided therapy or clinical status-guided therapy. There were more changes in "evidence-based" drugs as well as their daily doses in patients treated according to BNP levels. There was also a trend to lower the rate of heart failure worsening events in patients whose treatment was guided by plasma BNP levels.

机译：通过监测利钠肽水平引导的慢性心力衰竭患者的假设可以具有比患者临床状况（症状）为指导的常规治疗的更好的临床结果。该假设已经在几种随机临床试验（星BNP，Time-CHF，Prima）中进行了有争议的结果测试。在我们的Optima临床试验中，52例慢性心力衰竭患者随机化为脑钠尿肽（BNP） - 导致治疗或临床状态引导治疗。根据BNP水平治疗的患者的“基于证据”药物以及他们的日常剂量有更多的变化。还有一种趋势，以降低治疗血浆BNP水平的患者的心力衰竭恶化率。

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《International Congress on Coronary Artery Disease》|2009年||共6页
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Hradec J.; Krupicka J.; Janota T.;
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中图分类冠状动脉（粥样）硬化性心脏病（冠心病）;
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1. Management of chronic heart failure guided by individual N-terminal pro-B-type natriuretic peptide targets: results of the PRIMA (Can PRo-brain-natriuretic peptide guided therapy of chronic heart failure IMprove heart fAilure morbidity and mortality?) study. [J] . Eurlings LW, van Pol PE, Kok WE, Journal of the American College of Cardiology . 2010,第25期

机译：由单个N端前B型利尿钠肽靶向治疗指导的慢性心力衰竭的治疗：PRIMA（PRo-脑钠肽指导的慢性心力衰竭治疗可以改善心脏衰竭的发病率和死亡率吗？）研究的结果。
2. Ubiquinone Plasma Levels are Correlated with Brain Natriuretic Peptide Plasma Levels in Patients with Chronic Heart Failure: The Potential of Coenzyme Q10 Combined Therapy [J] . Zh.M. Sizova, V.L. Zakharova, K.A. Alibeyli, Serbian Journal of Experimental and Clinical Research . 2018,第2期

机译：慢性心力衰竭患者中泛醌血浆水平与脑钠肽血浆水平相关：辅酶Q10联合治疗的潜力
3. Improvement in structural and functional echocardiographic parameters during chronic heart failure therapy guided by natriuretic peptides: Mechanistic insights from the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) study [J] . WeinerR.B., BaggishA.L., Chen-TournouxA., European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2013,第3期

机译：利钠肽引导的慢性心力衰竭治疗期间结构和功能超声心动图参数的改善：ProBNP门诊量身定做的慢性心力衰竭（PROTECT）研究的机理见解
4. Treatment of chronic heart failure guided by plasma natriuretic peptide levels [C] . Hradec J., Krupicka J., Janota T. International Congress on Coronary Artery Disease . 2009

机译：血浆利钠肽水平引导的慢性心力衰竭治疗
5. Endocrine and paracrine aspects of vascular control: The effects of natriuretic peptides on human capacitance in health and chronic heart failure [D] . Schmitt, Matthias 2004

机译：血管控制的内分泌和旁静脉各方面：利钠肽对健康和慢性心力衰竭人人体电容的影响
6. Relationship between B-type natriuretic peptide plasma levels and echocardiography parameters in compensated chronic heart failure patients treated with levosimendan [O] . EJ de Almeida Figueiredo, A Perez, E Knobel, 2007

机译：左西孟旦治疗代偿性慢性心力衰竭患者B型利钠肽血浆水平与超声心动图参数之间的关系
7. Management of Chronic Heart Failure Guided by Individual N-Terminal Pro-B-Type Natriuretic Peptide Targets Results of the PRIMA (Can PRo-brain-natriuretic peptide guided therapy of chronic heart failure IMprove heart fAilure morbidity and mortality?) Study [O] . Eurlings, Luc W. M., van Pol, Petra E. J., Kok, Wouter E., 2010

机译：以单个N末端Pro-B型利尿钠肽为指导的慢性心力衰竭的治疗靶向PRIMA的结果（PRo-脑钠肽可指导慢性心力衰竭的治疗能否改善心衰的发病率和死亡率？）研究

Treatment of chronic heart failure guided by plasma natriuretic peptide levels

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