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Amino-terminal pro-bnp in patients with chronic heart failure: effect of disease severity, etiology, renal function and various clinical-laboratory indexes

机译:慢性心力衰竭患者氨基末端Pro-BNP:疾病严重程度,病因,肾功能和各种临床实验室指标的影响

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In patients with CHF different severity (NYHA II/III/IV) were measured anthro-pometric, metabolic, echochargiographic characteristics and plasma levels of amino-terminal pro-Brain Natriuretic Peptide (NT-proBNP). Ischemic/nonischemic patients groups were not differed by study parameters. Significant differences were found by NT-proBNP and other study parameters between NYHA II/III/IV F.C. groups. NT-proBNP was not differed between patients with BMI>25 vs BMI<25 and also with lymphocyte differential count <900, 900-1400, >1400 study groups. Significant differences were found when patients were divided by Creatinine clearance (CrCl) , left ventricular mass (LVM), LVMI and LVEF (%) quartiles. So, NT-proBNP indicates disease severity in CHF patients. In addition to the LVEF, it was correlated with LVM, LVMI. Renal function affects test performance. Some other test (e.g. lymphocyte differential count) apparently has an independent importance in assessment of patients with CHF.
机译:在CHF不同严重程度(NYHA II / III / IV)的患者中,测量氨基 - 末端促脑Natrietic肽(NT-PROPNP)的氨基 - 定位,代谢,回声摄影特征和血浆水平。缺血性/无际患者群体没有研究参数不同。 NT-probnp和Nyha II / III / IV / IV F.C的其他研究参数发现了显着差异。团体。 BMI> 25 VS BMI <25且淋巴细胞差分计数<900,900-1400,> 1400研究组的患者没有区别。当患者被肌酐清除(CRCL),左心室质量(LVM),LVMI和LVEF(%)四分位数除以患者时发现显着差异。因此,NT-probnp表明CHF患者中的疾病严重程度。除了LVEF之外,它与LVM,LVMI相关。肾功能会影响测试性能。其他一些测试(例如淋巴细胞差分计数)显然具有对评估CHF患者的独立重要性。

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