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首页> 外文会议>Asian Society for Mitochondrial Research and Medicine >Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA
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Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA

机译：线粒体转录因子A在维持线粒体DNA中

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摘要

Mitochondria have their own genome, which is essential for proper oxidative phosphorylation needed for a large part of ATP production in a cell. Although mitochondrial DNA-less (rho~0) cells can survive under special conditions, the integrity of the mitochondrial genome is critical for survival of multicellular organisms. Mitochondrial transcription factor A (TFAM), originally cloned as transcription factor, is essential for the maintenance of mtDNA. Recently, it has become known that TFAM plays critical roles in multiple aspects to maintain the integrity of mitochondrial DNA: transcription, replication, nucleoid formation, damage sensing, and DNA repair. The effects of TFAM in these aspects are intimately related to each other and to function as a whole for the purpose of maintenance of mtDNA.
机译：线粒体有自己的基因组，这对于细胞中大部分ATP生产所需的适当氧化磷酸化至关重要。虽然线粒体DNA - 较少（Rho〜0）细胞可以在特殊条件下存活，但线粒体基因组的完整性对于多细胞生物的存活至关重要。线粒体转录因子A（TFAM）最初被克隆为转录因子，对于维持MTDNA至关重要。最近，已知TFAM在多个方面起着关键作用以保持线粒体DNA的完整性：转录，复制，核形成，损伤感测和DNA修复。 TFAM在这些方面的影响与彼此密切相关，并以维持MTDNA的目的的整体起作用。

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