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首页> 外文会议>Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics >2D backward-mode photoacoustic imaging system for NIR (650-1200nm) spectroscopic biomedical applications
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2D backward-mode photoacoustic imaging system for NIR (650-1200nm) spectroscopic biomedical applications

机译：2D后向模式光声成像系统，用于NIR（650-1200nm）光谱生物医学应用

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A 2D photoacoustic imaging system for spectroscopic biomedical applications is reported, based on a Fabry-Perot (FP) polymer film ultrasound sensor. A variety of broadband sensors have been developed with bandwidths from 20MHz to 50MHz. These ultrasound sensors have a unique dichroic design which has an optical transmission window from 650nm to 1200nm and can be interrogated in the 1520-16 10nm wavelength region. This enables the system to operate in backward mode with a tunable Optical Parametric Oscillator (OPO) as the excitation source for near infrared (NIR) spectroscopic applications such as the measurement of blood oxygenation. The area over which the photoacoustic signals can be mapped is 4cm x 2.5cm with an optically defined element size of 64μm diameter. The system's noise-equivalent pressure (NEP) is 0.3kPa over a 20MHz bandwidth without signal averaging. The photoacoustic signals are mapped by rapidly scanning a focused laser beam over the surface of the sensor with a point to point acquisition time of 100ms. The spatial resolution of the imaging system, evaluated from tests on phantoms using a 50MHz FP sensor, is 37μm (lateral) x 27μm (vertical) FWHM. It is considered that this system has the potential to be used in applications that require high resolution 3D imaging of the structure and oxygenation status of the microvasculature.
机译：基于法布里 - 珀罗（FP）聚合物膜超声传感器，报道了一种用于光谱生物医学应用的2D光声成像系统。已经开发了各种宽带传感器，带宽为20MHz至50MHz。这些超声传感器具有独特的二向色设计，其具有从650nm至1200nm的光传输窗口，并且可以在1520-16 10nm波长区域中询问。这使得系统能够以可调谐光学参数振荡器（OPO）以后向模式以近红外（NIR）光谱应用的激励源在诸如血氧的测量。光声信号可以绘制的区域为4cm x 2.5cm，光学定义的元件尺寸直径为64μm。系统的噪音当量压力（NEP）在20MHz带宽上为0.3kPa而无需信号平均值。通过在传感器的表面上快速扫描聚焦激光束，光声信号通过点对点采集时间为100ms映射光声信号。从使用50MHz FP传感器的幻像测试中评估了成像系统的空间分辨率，是37μm（横向）×27μm（垂直）fwhm。认为该系统具有可用于需要高分辨率3D成像的应用的应用和微孔弹性的氧合状态。

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