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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >2D backward-mode photoacoustic imaging system for NIR (650-1200nm) spectroscopic biomedical applications
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2D backward-mode photoacoustic imaging system for NIR (650-1200nm) spectroscopic biomedical applications

机译：用于NIR（650-1200nm）光谱生物医学应用的2D后向模式光声成像系统

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摘要

A 2D photoacoustic imaging system for spectroscopic biomedical applications is reported, based on a Fabry-Perot (FP) polymer film ultrasound sensor. A variety of broadband sensors have been developed with bandwidths from 20MHz to 50MHz. These ultrasound sensors have a unique dichroic design which has an optical transmission window from 650nm to 1200nm and can be interrogated in the 1520-16 10nm wavelength region. This enables the system to operate in backward mode with a tunable Optical Parametric Oscillator (OPO) as the excitation source for near infrared (NIR) spectroscopic applications such as the measurement of blood oxygenation. The area over which the photoacoustic signals can be mapped is 4cm x 2.5cm with an optically defined element size of 64μm diameter. The system's noise-equivalent pressure (NEP) is 0.3kPa over a 20MHz bandwidth without signal averaging. The photoacoustic signals are mapped by rapidly scanning a focused laser beam over the surface of the sensor with a point to point acquisition time of 100ms. The spatial resolution of the imaging system, evaluated from tests on phantoms using a 50MHz FP sensor, is 37μm (lateral) x 27μm (vertical) FWHM. It is considered that this system has the potential to be used in applications that require high resolution 3D imaging of the structure and oxygenation status of the microvasculature.
机译：据报道，基于法布里-珀罗（FP）聚合物薄膜超声传感器的光谱生物医学应用的2D光声成像系统。已经开发出带宽从20MHz到50MHz的各种宽带传感器。这些超声传感器具有独特的二向色性设计，具有从650nm到1200nm的光传输窗口，可以在1520-16 10nm波长范围内进行查询。这使系统能够以可调光参量振荡器（OPO）作为后向模式运行，作为近红外（NIR）光谱应用（例如血液氧合测量）的激发源。可以映射光声信号的区域为4cm x 2.5cm，光学定义的元件直径为64μm。该系统的噪声等效压力（NEP）在20MHz带宽上为0.3kPa，无需信号平均。通过以100ms的点对点采集时间在传感器表面上快速扫描聚焦的激光束来映射光声信号。根据使用50MHz FP传感器对体模进行的测试评估，成像系统的空间分辨率为37μm（横向）x27μm（垂直）FWHM。认为该系统有潜力用于需要高分辨率3D成像的微血管结构和充氧状态的应用中。

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