Direct Discovery of Class I HLA Antigens That Distinguish Virus-Infected and Cancerous Cells

机译：直接发现I类HLA抗原，但区分病毒感染和癌细胞的抗原

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Class I HLA molecules are nature's proteome scanning chips. Class I HLA sample thousands of intracellular peptides, egress to the cell surface, and then act as peptidepresenting sentries on all cells of the body. Cells of the immune system then (1) survey the peptide cargo presented by these class I HLA sentries, (2) recognize class I HLA presented peptides unique to unhealthy cells, and (3) destroy unhealthy (cancerous and virus-infected) cells. A precise understanding of how class I HLA sentries distinguish diseased cells is positioned to drive immune-based diagnostics, therapies, and vaccines.

机译：I类HLA分子是大自然的蛋白质组扫描芯片。 I类HLA样本千分之一的细胞内肽，出口到细胞表面，然后用作身体的所有细胞上的肽蛋白哨。免疫系统的细胞然后（1）调查这些类HLA Sentries提出的肽货物，（2）识别I类HLA呈现出不健康细胞特异性的肽，（3）摧毁不健康（癌症和病毒感染的）细胞。准确了解I类HLA Sentries如何区分患病细胞的定位以驱动基于免疫的诊断，疗法和疫苗。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2006年||共2页
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W. Hildebrand; A. Wahl; H. Hickman-Miller; W. Bardet; K. Jackson; J. Weidanz;
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1. Direct class I HLA antigen discovery to distinguish virus-infected and cancerous cells. [J] . Wahl A, Weidanz J, Hildebrand W Expert review of proteomics . 2006,第6期

机译：直接I类HLA抗原发现可区分病毒感染的细胞和癌细胞。
2. Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. Selective involvement of CD8 in their class I--directed cytotoxicity. [J] . P Aparicio, D Jaraquemada, J A López de Castro The Journal of Experomental Medicine . 1987,第2期

机译：具有HLA-B27和HLA-DR2抗原双重识别的同种反应性溶细胞性T细胞克隆。 CD8选择性参与其I类-细胞毒性。
3. Cytotoxic T lymphocytes directed against donor HLA class I antigens on airway epithelial cells are present in bronchoalveolar lavage fluid from lung transplant recipients during acute rejection. [J] . Nakajima J, Poindexter NJ, Hillemeyer PB, The Journal of Thoracic and Cardiovascular Surgery . 1999,第3期

机译：在急性排斥反应期间，来自肺移植受者的支气管肺泡灌洗液中存在针对气道上皮细胞上的供体HLA I类抗原的细胞毒性T淋巴细胞。
4. Direct Discovery of Class I HLA Antigens That Distinguish Virus-Infected and Cancerous Cells [C] . W. Hildebrand, A. Wahl, H. Hickman-Miller, ASMS Conference on Mass Spectrometry and Allied Topics . 2006

机译：直接发现I类HLA抗原，但区分病毒感染和癌细胞的抗原
5. Epigenetically Silenced Class I Human Leukocyte Antigen (HLA-I): A Novel Biomarker and Therapeutic Target in Prostate Cancer [D] . Rodems, Tamara Stephanie. 2020

机译：表演沉默的I型人白细胞抗原（HLA-1）：一种新的生物标志物和前列腺癌治疗靶标
6. Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. Selective involvement of CD8 in their class I-- directed cytotoxicity [O] . 1987

机译：具有HLA-B27和HLA-DR2抗原双重识别的同种反应性溶细胞性T细胞克隆。 CD8选择性参与其I类定向的细胞毒性
7. Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. Selective involvement of CD8 in their class I-- directed cytotoxicity [O] . 1987

机译：具有HLA-B27和HLA-DR2抗原双重识别的同种反应性溶细胞性T细胞克隆。 CD8选择性参与其I类定向的细胞毒性

Direct Discovery of Class I HLA Antigens That Distinguish Virus-Infected and Cancerous Cells

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