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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Depletion effect of High-abundance Urine Proteins for Detecting Markers of Bladder Cancer in Urine by Quantitative Mass Spectrometry
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Depletion effect of High-abundance Urine Proteins for Detecting Markers of Bladder Cancer in Urine by Quantitative Mass Spectrometry

机译：用定量质谱法测定尿液中膀胱癌标志物的耗竭效应

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Bladder cancer is the most common malignancy in urinary tract. An accurate biomarker not only helps physicians to estimate the risk of recurrence but also reduce the number of cystoscopy performed which is invasive and costly. Several marker candidates of bladder tumor discovered from urine and cells have been reported. However, a urine-based assay does not hold superior properties in both sensitivity and specificity currently. Concentration dynamic range of urinary proteins exists and suppresses the detection of minor proteins. No commercial product for depletion of high-abundance urine proteins is available currently. We developed a facile method for depleting the three most abundant urinary proteins. The condition was optimized to study the different urine proteomes of bladder cancer by quantitative MS.
机译：膀胱癌是泌尿道中最常见的恶性肿瘤。准确的生物标志物不仅有助于医生估计复发风险，而且还减少了侵入性和昂贵的膀胱镜检查的数量。据报道，来自尿液和细胞发现的膀胱肿瘤的几个标记候选者。然而，基于尿基测定目前不会在敏感性和特异性中保持优异的性质。浓度的尿蛋白的动态范围存在并抑制次蛋白的检测。目前无法提供用于耗尽高丰盈尿蛋白的商业产品。我们开发了一种耗尽三种最丰富的尿蛋白的容易方法。优化该条件以通过定量MS研究膀胱癌的不同尿蛋白。

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