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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >Mapping Calmodulin-induced Conformational Changes During Activation of Neuronal Nitric Oxide Synthase by H/D Exchange Mass Spectrometry.
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Mapping Calmodulin-induced Conformational Changes During Activation of Neuronal Nitric Oxide Synthase by H/D Exchange Mass Spectrometry.

机译：H / D兑换质谱法在神经元一氧化氮合酶激活过程中诱导钙调蛋白诱导的构象变化。

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摘要

The diatomic gas nitric oxide (NO) serves dual physiological roles as both a signaling molecule and an inflammation agent. Nitric oxide synthases (NOS) are large, multi-domain hemoproteins responsible for production of NO. Emitted at minute concentrations, NO is a membrane-permeable paracrine signaling agent. Generated at high levels, NO acts as a potent cytotoxic weapon of the immune system. As a fairly reactive free radical, NO production is tightly regulated. NOS regulation is especially important for synaptic NO signaling. NO is uniquely well-suited for local, omnidirectional neurotransmission because it is a short-lived, freely diffusible gas. Unlike classical neurotransmitters, NO cannot be stored in vesicles. Control over NO signaling is exerted by regulating localization and activation. Strict regulation of NO production is vital, as NO surges are a prominent mediator of excitotoxicity.
机译：抗原氨基型气体一氧化氮（NO）用于双重生理角色，作为信号分子和炎症剂。一氧化氮合成酶（NOS）是大，多域血栓蛋白，负责生产NO。在微小浓度下发射，NO是膜可渗透的旁静脉信号剂。在高水平产生，没有作为免疫系统的有效细胞毒性武器。作为一个相当反应的自由基，没有生产严格调节。 NOS规则对于突触没有信令尤为重要。否是唯一适合当地的全环，因为它是短暂的，可自由扩散的气体。与古典神经递质不同，否不能存放在囊泡中。通过调节本地化和激活来施加无信号传导。严格监管没有生产是至关重要的，因为没有兴奋的兴奋毒性突出蛋白。

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