首页> 外文会议>Hemophilia Symposium >In Vivo-Assay for Warfarin-Resistance by Coexpression of VK0RC1 and Vitamin K-Dependent Coagulation Factors

【24h】

In Vivo-Assay for Warfarin-Resistance by Coexpression of VK0RC1 and Vitamin K-Dependent Coagulation Factors

机译：在VK0RC1和维生素K依赖性凝血因子的共同抑制方面的体内测定

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Vitamin K serves as a cofactor for the post-translational modification by gamma-car-boxylation of several proteins with Gla-domains. Vitamin K-dependent proteins include the coagulation factors II, VII, IX, and X and proteins S, C and Z, illustrating the therapeutic importance of vitamin K metabolism. Inhibitors of the Coumarin-type like Warfarin or Marcumar reduce coagulation activity by interfering with the vitamin K 2,3-epoxide reductase enzyme complex (VKOR). They are the most used oral anticoagulants for antithrombotic prophylaxis.Previously we have shown that mutations in the VK0RC1 lead to combined deficiency of vitamin-K-dependent clotting factors type 2 (VKCFD2; OMIM: 607473) or Warfarin resistance.

机译：维生素K用作由Gamma-Car-Boxy化与GLA结构蛋白的γ-型丙烷化的翻译后修饰的辅助因子。维生素K依赖性蛋白质包括凝血因子II，VII，IX和X和蛋白S，C和Z，说明维生素K代谢的治疗重要性。香豆素型的抑制剂如华法林或Marcumar等通过干扰维生素K 2,3-环氧化物还原酶酶（VKOR）来减少凝血活性。它们是抗血栓性预防最常用的抗凝血剂。因此，我们已经表明，VK0RC1中的突变导致维生素-K依赖性凝血因子2型（VKCFD2; OMIM：607473）或华法素抗性的组合缺乏。

著录项

来源
《Hemophilia Symposium》|2008年||共2页
会议地点
作者
A.Fregin; S.Rost; C.R.Muller; J. Oldenburg;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类出血性疾病;
关键词

相似文献

外文文献
中文文献
专利

1. VK0RC1: A Warfarin-Sensitive Enzyme in Vitamin K Metabolism and Biosynthesis of Vitamin K-Dependent Blood Coagulation Factors [J] . Reidar Wallin, Nadeem Wajih, Susan M. Hutson Vitamins and hormones. . 2008,第0期

机译：VK0RC1：维生素K代谢和维生素K依赖性血液凝固因子的生物合成中的华法林敏感酶
2. Antenatal administration of vitamin K1: Relationship to vitamin K-dependent coagulation factors and incidence rate of periventricular-intraventricular hemorrhage in preterm infants; Egyptian randomized controlled trial [J] . El-GanzouryM.M., El-FarrashR.A., SaadA.A., The journal of maternal-fetal & neonatal medicine . 2014,第7a8期

机译：维生素K1的产前管理：与维生素K依赖的凝血因子和早产儿脑室-脑室内出血的发生率有关;埃及随机对照试验
3. Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infant [J] . Liu J, Wang Q, Gao F, Journal of Perinatal Medicine . 2006,第2期

机译：产前维生素K1的孕妇产前给药可增加脐血中维生素K依赖性凝血因子的活性，并降低早产儿脑室-脑室内出血的发生率
4. In Vivo-Assay for Warfarin-Resistance by Coexpression of VK0RC1 and Vitamin K-Dependent Coagulation Factors [C] . A.Fregin, S.Rost, C.R.Muller, Hemophilia Symposium . 2008

机译：在VK0RC1和维生素K依赖性凝血因子的共同抑制方面的体内测定
5. Discovery of inactive E* conformations in thrombin and other vitamin K-dependent clotting proteases. [D] . Bah, Alaji. 2009

机译：在凝血酶和其他依赖维生素K的凝血蛋白酶中发现非活性E *构象。
6. Vitamin K2 Supplementation Does Not Affect Vitamin K-Dependent Coagulation Factors Activity in Healthy Subjects: A Pilot Study [O] . Jing Tan, Ruijun Ren, Dan Xu 2020

机译：补充维生素K2不会影响健康受试者中依赖于维生素K的凝血因子的活性：一项初步研究
7. Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX) [O] . Antonio Girolami, Silvia Ferrari, Elisabetta Cosi, 2018

机译：维生素K依赖性凝血因子可能是出血和血栓形成（FII，FVII和FIX）

In Vivo-Assay for Warfarin-Resistance by Coexpression of VK0RC1 and Vitamin K-Dependent Coagulation Factors

摘要

著录项

相似文献

相关主题

期刊订阅