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首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >TransOmics study of the saliva of children with autism spectrum disorder using high definition mass spectrometry
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TransOmics study of the saliva of children with autism spectrum disorder using high definition mass spectrometry

机译：高清晰度质谱法自闭症谱紊乱儿童唾液研究

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HDMS~E allows for high peak capacity analyses maximizing protein identification whilst retaining label-free quantification capabilities. PCA of the data using TransOmics informatics software shows a clear differentiation between the ASD and control phenotypes. Relative quantification analysis of the two conditions was performed in a label free manner using the HDMSE data generated in the SYNAPT G2S experiment. 174 regulated proteins (p <0.05/fold change > 2) between the two phenotypes have been retained for further investigation. Reactome pathway analysis conducted with the qualitative and quantitative results of the TransOmics informatics analysis highlighted dysregulation of the complement pathway in the ASD patients. Other pathways were also implicated implicating overall immunity problems in ASD phenotype. Findings of the pilot study are consistent with current theories of ASD etiology and serum proteomic studies but also point toward previously unidentified markers and deficits in ASD. Regulated proteins provide new avenues of research for a non-invasive saliva based diagnosis for ASD. Studies examining larger participant numbers are warranted.
机译：HDMS〜E允许高峰穴容量分析，同时保持无标签的定量能力。使用Transomics Informatics软件的数据的PCA显示ASD和控制表型之间的明显差异。使用Synapt G2S实验中生成的HDMSE数据以标记的方式进行两个条件的相对量化分析。已经保留了两种表型之间的调节蛋白（P <0.05 /倍变化> 2）进行进一步调查。随着正组态信息分析的定性和定量结果进行了反应途径分析，突出了ASD患者的补体途径的失调。其他途径也涉及ASD表型中的总体免疫问题。试点研究的调查结果与亚本病因和血清蛋白质组学研究的当前理论一致，但也指向ASD中以前未识别的标记和缺陷。调节蛋白质为ASD的非侵入性唾液诊断提供了新的研究途径。有必要研究较大的参与者编号。

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