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首页> 外文会议>American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics >Can structural elements of proteins be identified by mass spectrometry and rapid derivatization in electrospray plumes? Can structural elements of proteins be identified by mass spectrometry and rapid derivatization in electrospray plumes?
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Can structural elements of proteins be identified by mass spectrometry and rapid derivatization in electrospray plumes? Can structural elements of proteins be identified by mass spectrometry and rapid derivatization in electrospray plumes?

机译：蛋白质的结构元素可以通过质谱法和电喷雾羽毛的快速衍生来鉴定蛋白质吗？蛋白质的结构元素可以通过质谱法和电喷雾羽毛的快速衍生来鉴定蛋白质吗？

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The label percentages are used as input in JmolScripter; assigning a color to each percentage value and overlaying the NMR structures of α-conotoxin GI with the percent labeling data. This gives a picture of where the most labeling is occurring along with several inferred explanations. The amino acids that underwent the most labeling are on the C-terminal tail of the peptide, whereas the amino acids that did not undergo very much labeling are on the N-terminal tail of the peptide and part of the α-helix. This was to be expected from the NMR and x-ray structures which show the C-terminus as more exposed to solvent while the N-terminus is held in the interior of the peptide by the disulfide bonds. This rigid structure explains the lower labeling in those areas.
机译：标签百分比用作JMOLSCRIPTER中的输入;将颜色分配给每个百分比值并将α-conotoxin gi的NMR结构与标记数据百分比覆盖。这给出了大多数标签发生的地方以及几个推断的解释。氨基酸在肽的肽的C末端尾部上，而没有经历过大标记的氨基酸在肽的N-末端尾部和部分α-螺旋。从NMR和X射线结构预期，在通过二硫键在肽的内部保持在溶剂中的C-末端，该X射线结构预期。这种刚性结构解释了这些区域的较低标记。

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