SELECTIVE CELL TARGETING BY SYNERGISTIC INTERACTIONS OF PEPTIDE AND GLYCANS

机译：通过肽和聚糖的协同相互作用靶向选择性细胞

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In the field of molecular imaging, the target selectivity is one of the most important factors in determining the degree of imaging contrast. Many studies have focused on developing ligands with high-affinity to surface receptors of interests. However, it is sometimes difficult to find specific surface receptor to the target. In addition, the "strongly" interacting ligands to the target, e.g., cancer cells, often give high background, when the same receptor can also be expressed on the other cells (even to lesser extent), hence resulting in poor imaging contrast.

机译：在分子成像领域中，目标选择性是确定成像程度对比度的最重要因素之一。许多研究侧重于开发具有高亲和力的配体对感兴趣的表面受体。然而，有时难以找到目标的特定表面受体。另外，当相同的受体也可以在其他细胞（甚至更小的程度）上表达时，癌细胞通常会给靶向靶向靶向靶向靶标配体，通常会给高背景。因此，导致成像对比度差。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Shoqo Nomura; Misako Taichi; Yasuko Egawa;
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中图分类碳水化合物、糖;
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1. Impact of T-cell receptor Vbeta haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus. [J] . Yoshioka T, Imura K, Hikita I, Immunology: An Official Journal of the British Society for Immunology . 2007,第1期

机译：T细胞受体Vbeta单倍型对DS-Nh小鼠皮炎发展的影响：由葡萄球菌肠毒素C和金黄色葡萄球菌肽聚糖引起的白介素13的协同产生。
2. Synergistic targeted delivery of payload into cancer cells using liposomes co-modified with photolabile-caged cell-penetrating peptides and targeting ligands [J] . Yang Yang, Yang Yanfang, Xie Xiangyang, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2015,第Null期

机译：使用与光不稳定笼罩的细胞穿透肽和靶向配体共修饰的脂质体，将靶向有效负载有效地递送至癌细胞
3. Cell-based glycan arrays for probing glycan–glycan binding protein interactions [J] . Jennie Grace Briard, Hao Jiang, Kelley W. Moremen, Nature Communications . 2018,第1期

机译：基于细胞的聚糖阵列，用于探测聚糖与聚糖结合蛋白的相互作用
4. SELECTIVE CELL TARGETING BY SYNERGISTIC INTERACTIONS OF PEPTIDE AND GLYCANS [C] . Shoqo Nomura, Misako Taichi, Yasuko Egawa International Carbohydrate Symposium . 2018

机译：通过肽和聚糖的协同相互作用靶向选择性细胞
5. High-Throughput Drug Screen To Identify Compounds Working Selectively and Synergistically With CQ To Inhibit Proliferation of TSC-2 Deficient Cells [D] . Sanin, Andres F. 2019

机译：高通量药物筛选用CQ选择性和协同地鉴定化合物，以抑制TSC-2缺陷细胞的增殖
6. Impact of T-cell receptor Vβ haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus [O] . Takeshi Yoshioka, Kinichi Imura, Ichiro Hikita, 2007

机译：T细胞受体Vβ单倍型对DS-Nh小鼠皮炎发展的影响：由葡萄球菌肠毒素C和金黄色葡萄球菌肽聚糖引起的白介素13的协同产生
7. Impact of T-cell receptor Vβ haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus [O] . Yoshioka, Takeshi, Imura, Kinichi, Hikita, Ichiro, 2007

机译：T细胞受体Vβ单倍型对DS-Nh小鼠皮炎发展的影响：由葡萄球菌肠毒素C和金黄色葡萄球菌肽聚糖引起的白介素13的协同产生

SELECTIVE CELL TARGETING BY SYNERGISTIC INTERACTIONS OF PEPTIDE AND GLYCANS

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