CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS SUIS: POTENTIAL AS VACCINE ANTIGENS

机译：Suis的链球菌荚膜多糖：潜在疫苗抗原

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Streptococcus suis is an encapsulated bacterium and one of the most important swine pathogens and a zoonotic agent for which no effective vaccine exists. To date, 35 serotypes have been described based on capsular polysaccharide (CPS) antigenic diversity. Globally, the predominant S. suis serotypes isolated from clinical cases in pigs are, in decreasing order, types 2, 9, 3, 1/2, 7, 8, 4, 22, 5, and 1 [1]. So far, we have reported the repeating unit structures for the CPSs of types 2 [2], 14 [3], 1 and 1/2 [4], and 9 [5]. The CPSs of types 2 and 14 are known to be poor activators of antigen-presenting cells (APC): stimulation with these CPSs induces secretion of CCL2 and CCL3 only, with no production of IL-1ss, IL-6, TNF, IL-12p70 or IL-10 [6]. Additionally, types 2 and 14 CPSs are non-immunogenic in mice with undetectable levels of anti-CPS antibodies [7].

机译：Scopocccus Suis是一种包封的细菌，也是最重要的猪病原体和一种无效疫苗的一种猪病理剂。迄今为止，已经基于荚膜多糖（CPS）抗原多样性描述了35种血清型。在全球范围内，从猪临床病例中分离的主要S. Suis血清型在递减顺序，类型2,9,3,1 / 2,7,8,4,22,5和1 [1]中。到目前为止，我们已经报道了2型[2]，14，1和1/2 [4]的CPS的重复单元结构，和9 [5]。已知2和14种和14种的CPS是抗原呈递细胞的差的激活剂（APC）：用这些CPS的刺激仅诱导CCL2和CCL3的分泌，没有产生IL-1SS，IL-6，TNF，IL- 12p70或IL-10 [6]。另外，2和14种CPS在小鼠中是非免疫原性，具有未检测的抗CPS抗体水平[7]。

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《International Carbohydrate Symposium》|2018年|832 p.|共1页
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Guillaume Govette-Desiardins; Evgeny Vinogradov; Marie-Rose Van Calsteren;
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中图分类碳水化合物、糖;
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1. Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation [J] . Masatoshi Okura, Daisuke Takamatsu, Fumito Maruyama, Applied and Environmental Microbiology . 2013,第8期

机译：猪链球菌所有血清型荚膜多糖合成基因簇的遗传分析：产生荚膜变异的潜在机制。
2. Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation [J] . Masatoshi Okura, Daisuke Takamatsu, Fumito Maruyama, Applied Microbiology . 2013,第8期

机译：猪链球菌所有血清型荚膜多糖合成基因簇的遗传分析：产生荚膜变异的潜在机制。
3. Protection against Streptococcus suis Serotype 2 Infection Using a Capsular Polysaccharide Glycoconjugate Vaccine [J] . Guillaume Goyette-Desjardins, Cynthia Calzas, Tze Chieh Shiao, Infection and immunity . 2016,第7期

机译：使用荚膜多糖糖缀合物疫苗预防猪链球菌血清型2感染
4. CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS SUIS: POTENTIAL AS VACCINE ANTIGENS [C] . Guillaume Govette-Desiardins, Evgeny Vinogradov, Marie-Rose Van Calsteren International Carbohydrate Symposium . 2018

机译：Suis的链球菌荚膜多糖：潜在疫苗抗原
5. Studies of peptide mimicry of the group B streptococcus type III capsular polysaccharide antigen. [D] . Pomwised, Rattanaruji. 2007

机译：B组链球菌III型荚膜多糖抗原的肽模拟研究。
6. Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation [O] . Masatoshi Okura, Daisuke Takamatsu, Fumito Maruyama, 2013

机译：猪链球菌所有血清型荚膜多糖合成基因簇的遗传分析：产生荚膜变异的潜在机制。
7. A capsular polysaccharide-expressing live vaccine suppresses streptococcal toxic shock-like syndrome and provides sequence type-independent protection during Streptococcus suis infection [O] . Zhiwei Li, Peixi Chang, Jiali Xu, 2018

机译：表达囊状多糖的活疫苗抑制了链球菌毒性休克综合征，并在链球菌感染期间提供序列类型无关的保护
8. Dendritic Cell-Derived Exosomes Express a Streptococcus pneumoniae Capsular Polysaccharide Type 14 Cross-Reactive Antigen That Induces Protective Immunoglobulin Responses against Pneumococcal Infection in Mice [R] . Colino, J., Snapper, C. M. 2007

机译：树突状细胞衍生外泌体表达肺炎链球菌荚膜多糖14型交叉反应抗原诱导保护性免疫球蛋白对小鼠肺炎球菌感染的反应

CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS SUIS: POTENTIAL AS VACCINE ANTIGENS

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