Effective operational methodology of extrusion could impact pharmaceutical properties of polymer ranging from fundamental studies of mechanical and chemical mechanisms. Applied shear stress can regulate the polymer mixing as well as properties such as percentage of relative humidity. Polymer behavior differs in different operating conditions such as screw speed of extruder, specific throughput and barrel temperature. Combinations of such process parameters could directly affect the degree of polymer reaction in terms of percentage of breakup and water degradation. Yet, it is very complicated to determine the effective methodology for polymer extrusion process because the viscous drag pressure depends on some other parameters such as maximum temperature, screw design and the fill ratio. Here we present a novel approach to include barrel temperature and number of revolutions of extruder to correlate the pharmaceutical properties with the degree of combined mechanical mechanism. Design of Experiment (DOE) was being modified to determine property responses based on statistical significance. A 3-D Central Composite Design (CCD) grid was formulated to predict operational equation for percentage breakup and percentage of relative humidity.
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