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首页> 外文会议>International Conference on the Development of Biomedical Engineering in Vietnam >Nanoliposomes as an Efficient Drug Carrier System for Paclitaxel Delivery
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Nanoliposomes as an Efficient Drug Carrier System for Paclitaxel Delivery

机译：纳米脂质为紫杉醇递送的有效药物载体系统

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Paclitaxel (PTX), a compound extracted from the Pacific yew tree (Taxus brevifolia), is widely used as a natural-source cancer drag in the treatment of ovarian, breast and lung cancers. Previous studies showed that PTX had obvious effects on cancer cells, it blocks the cell cycle in its G1 or M phases by stabilizing the microtubules and preventing depolymerization. However, the use of PTX is inconvenient and associated with significant and poorly predictable side effects, due to its low bioavailability and poor water solubility. The aim of this study was to develop PTX-loaded soy lecithin nanolipo-somes (PTX--LP) to improve its bioavailability. In this study, PTX-LP was prepared by thin film hydration method. The average size, polydispersity index (PDI), zeta potential and encapsulation efficiency (EE) of the PTX-LP were characterized. Results indicated that PTX-LP was able to loaded with suitable encapsulation efficiency values, nanometric particle size (100-200 run), low polydispersity (less than 0.5), negative zeta potential, and slowly released up to 96 h. Therefore, the study expected that PTX-LP developed herein would serve as a potent drug carrier system for PTX in cancer therapy.
机译：紫杉醇（PTX），从太平洋紫杉树（Rapus Brevifolia）中提取的化合物，被广泛用作卵巢，乳腺癌和肺癌的自然癌症阻力。以前的研究表明，PTX对癌细胞具有明显的影响，通过稳定微管和防止解聚，阻断其G1或M相中的细胞周期。然而，由于其低生物利用度和水溶解度差，PTX的使用不方便并且与可预测的副作用具有显着且可预测的副作用。该研究的目的是开发PTX加载的大豆卵磷脂纳米脂 - 题（PTX - LP）以改善其生物利用度。在该研究中，PTX-LP通过薄膜水合方法制备。 PTX-LP的平均尺寸，多分散指数（PDI），Zeta电位和封装效率（EE）的特征在于。结果表明，PTX-LP能够加载合适的封装效率值，纳米粒径（100-200次），低多分散度（小于0.5），负Zeta电位，并缓慢释放到96小时。因此，该研究预期本文开发的PTX-LP将用作癌症治疗中PTX的有效药物载体系统。

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