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A common antigenic peptide of several HCV proteins

机译：几种HCV蛋白的常见抗原肽

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Hepatitis C virus (HCV), a member of the Flaviviridae family of positive-strand RNA viruses, is the major etiologic agent of vital non-A, non-B hepatitis. Numerous studies have indicated that most HCV-infected individuals will becoem chronic carriers, a stage that may lead to development of cirrhosis and hepatocellular carcinoma [1,2]. Thus, it is very important to develop a specific and sensitive diagnosis for the detection of HCV antibodies at an early phase of HCV infection and an efficient anti-HCV vaccine in HCV-infected control. Geographically distinct isolates have been molecularly cloned and sequenced. Sequence analysis revealed that the hCV genome is approximately 9400 nucleotides long, encoding a 3011-amino acid polyprotein [3]. Up to now, many sequences of putative HCV proteins have been reported. Among these proteins, envelope protein and envelope protein E1, core envelope protein, genome polyprotein and precursor protein may serve as important targets for anti-HCV vaccine development, since they are likely to be involved in host range immune selection, virus neutralization and persistent infection properties of virus [4]. In order to determine the most immunogenic regions, after analyzing the sequences of several putative HCV proteins, a common antigenic peptide shared by these putative hCV proteins was synthesized. This peptide may be valuable for studies of HCV diagnosis and vaccine development.
机译：丙型肝炎病毒（HCV），黄病毒科的正链RNA病毒的一员，是至关重要的非A，非B型肝炎的主要病原体。许多研究表明，大多数HCV感染者将becoem慢性携带者，一个阶段，可能会导致肝硬化和肝细胞癌[1,2]的发展。因此，这是非常重要的丙型肝炎病毒感染的早期阶段，在HCV感染控制的有效的抗HCV疫苗开发用于检测HCV抗体的特异性和敏感性诊断。地理上不同的菌株已经分子克隆和测序。序列分析表明，HCV基因组是约9400个核苷酸长，编码3011个氨基酸的多聚蛋白[3]。截至目前，已有报道推测的HCV蛋白的许多序列。在这些蛋白中，包膜蛋白和包膜蛋白E1，核包膜蛋白，基因组蛋白和前体蛋白可作为抗HCV疫苗发展的重要目标，因为他们很可能会在宿主范围的免疫选择，病毒中和持续感染参与病毒的性质[4]。为了确定最免疫原性区域，分析几个推测的HCV蛋白的序列之后，一个共同的抗原性肽由这些推定的HCV蛋白共享的合成。这种肽可用于HCV诊断和疫苗开发的研究价值。

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