首页> 外文会议>Chinese peptide symposium >Synthesis and structure-activity relationships of tripeptide mimetic analogs of ACE inhibitors

【24h】

Synthesis and structure-activity relationships of tripeptide mimetic analogs of ACE inhibitors

机译：ACE抑制剂三肽模拟物的合成与结构 - 活性关系

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Angiotensin converting enzyme (ACE) inhibitors hold great promise in the treatment of hypertension [1]. As more is learned about the design and synthesis of protease inhibitors, the replacement of amide backbone by a structure-like surrogate to impart conformational integrity or resist proteolytic degradation cna be a promising approach. esynthesized two types of tripeptide mimetic analogs and explored their structure-activity relationships with aim of identifying highly potent and low side effect ACE inhibitors.

机译：血管紧张素转化酶（ACE）抑制剂在高血压治疗中具有很大的希望[1]。随着蛋白酶抑制剂的设计和合成更多，通过结构状替代物更换酰胺骨架以赋予构象完整性或抗蚀剂蛋白水解降解CNA是有希望的方法。敏捷化了两种三肽模拟类似物，并探讨了它们的结构 - 活性关系，目的是鉴定高效和低副作用ACE抑制剂。

著录项

来源
《Chinese peptide symposium》|1998年||共2页
会议地点
作者
Shi-Feng Liu; Jie-Cheng Xu;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类抗体蛋白与干扰素蛋白;
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from plasmodium falciparum [J] . Kannan Sivaraman K., Paiardini A., Sieńczyk M., Journal of Medicinal Chemistry . 2013,第12期

机译：作为恶性疟原虫M1和M17氨基肽酶抑制剂的膦精氨酸模拟物的合成及其构效关系
2. Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the (D)-Arg-Gly-Arg tripeptide sequence. [J] . Marlowe CK, Sinha U, Gunn AC, Bioorganic and Medicinal Chemistry Letters . 2000,第1期

机译：一系列精氨酸醛因子Xa抑制剂的设计，合成及构效关系第1部分：基于（D）-Arg-Gly-Arg三肽序列的结构。
3. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-(3-methylbutyl)-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring. [J] . Rockway TW, Zhang R, Liu D, Bioorganic and Medicinal Chemistry Letters . 2006,第14期

机译：HCV NS5B聚合酶抑制剂：芳香环上含有取代基的N-1-苄基和N-1-（3-甲基丁基）-4-羟基-1,8-萘啶-3-基苯并噻二嗪类似物的合成与构效关系。
4. Synthesis and structure-activity relationships of tripeptide mimetic analogs of ACE inhibitors [C] . Shi-Feng Liu, Jie-Cheng Xu Chinese peptide symposium . 1998

机译：ACE抑制剂三肽模拟物的合成与结构 - 活性关系
5. Part I. Isolation of natural product inhibitors and synthesis of inhibitors of signal transduction. Part II. Structure-activity relationship for a series of glycosidase inhibitors. [D] . Fraser, Rebecca Dawn. 1993

机译：第一部分：天然产物抑制剂的分离和信号转导抑制剂的合成。第二部分一系列糖苷酶抑制剂的构效关系。
6. Synthesis structure and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic. [O] . R. Krishnan, A. Tulinsky, G. P. Vlasuk, 1996

机译：含有α-酮基酰胺过渡态模拟物的二价凝血酶抑制剂的合成结构和构效关系。
7. Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum. [O] . Kannan Sivaraman K, Paiardini A, Sieńczyk M, 2013

机译：作为恶性疟原虫M1和M17氨基肽酶抑制剂的膦精氨酸模拟物的合成及其构效关系。

Synthesis and structure-activity relationships of tripeptide mimetic analogs of ACE inhibitors

摘要

著录项

相似文献

相关主题

期刊订阅