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Involvement of a G-protein coupled receptor (GPCR) in signal transduction induced by arginine-vasopressing(4-8)

机译:G-蛋白偶联受体(GPCR)参与精氨酸 - 血管加压加压率诱导的信号转导(4-8)

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Arginine-vasporessin fragment AVP(4-8) had a high affinity receptor in rat hippocamous [1,2], and a remarkable induced long-term potentiation (LTP) of synaptic transmission via a N-methyl-D-aspartic acid-receptor (NMDA-R) plus mechanism [3]. It was reported that a pertussis toxin (PTX)-sensitive G protein was involved in tetanus-induced LTP in rat hippocampus [4]. In order to study the receptor that may be involved in LTP process stimulated by AVP (4-8) and the signaling pathway, changes of Mitogen-activated protein kinase (MAPK) activity and Ca~2+/CaM-dependent protein kinarseII (CaMKII) autophosphorylation influenced by ZDC(C)PR, PTX, etc. were estimated and their significance was discussed.
机译:Aginine-vascoressin片段AVP(4-8)在大鼠Hippocamous [1,2]中具有高亲和力受体,以及通过N-甲基-D-天冬氨酸 - 受体的显着诱导的长期增强(LTP)的突触传递(nmda-r)加机制[3]。据报道,在大鼠海马的破伤风诱导的Tetanus诱导的LTP中涉及百日咳毒素(PTX)-Sisisive G蛋白[4]。为了研究可参与由AVP(4-8)刺激的LTP过程的受体和信号通路,丝裂原活化蛋白激酶(MAPK)活性的变化和Ca〜2 + / Cam依赖性蛋白质Kinarseii(Camkii估计受ZDC(C)PR,PTX等影响的自磷酸化,并讨论了它们的意义。

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