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Effect of Chitosan Salts on Controlled Release Property of Chitosan hydrogels

机译：壳聚糖盐对壳聚糖水凝胶控制脱模性能的影响

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Hydrogels are widely used for controlled release applications because of their soft tissue biocompatibility, the ease with which the drugs are dispersed in the matrix and the high degree of control achieved by selecting the physical and chemical properties of the polymer network. Hydrogels consist of polymer chains crosslinked to each other to create a tangled mesh structure, providing a matrix for the entrapment of drugs. Chitosan, a cationic polysaccharide, is obtained by alkaline deacetylation of chitin, the principal exoskeletal component in crustaceans1. Chitosan is reported to be non-toxic and bioabsorbable2, and has been explored for the release of many drugs because of its mucoadhesivity and ability to enhance the penetration of drugs3-4. The swelling kinetics and release properties of crosslinked chitosan and chitosan/polymer blending matrices have been reported, the effect of molecular parameters of chitosan on controlled release property has also been studies, but the reported studies on the effect of chitosan acid salt on controlled release property was few. So the aim of this study was to prepare three chitosan hydrogels based on three typical kinds of acid, widely used as solvent of chitosan, to observe their morphology and structure by SEM, and to investigate the influence of acid salts on swelling behavior and controlled release property of chitosan hydrogels in simulating periodontal pocket environment using tetracycline HCl widely used in periodontitis treatment as model drugs.
机译：水凝胶广泛用于受控释放应用，因为它们的软组织生物相容性，药物分散在基质中的易容易和通过选择聚合物网络的物理和化学性质来实现的高度控制。水凝胶由共聚合物链组成，彼此交联以产生缠结的网状结构，为药物夹带提供基质。壳聚糖，一种阳离子多糖，通过甲壳素的碱性脱乙酰化，甲壳类动物中的主要外壳组分获得。据据报道，壳聚糖是无毒的和生物中的2，并且由于其粘附性和增强药物渗透的能力，已经探索了许多药物的释放。据报道了交联的壳聚糖和壳聚糖/聚合物共混基质的肿胀动力学和脱裂性质，壳聚糖分子参数对控释性的影响也是研究，但报道的研究壳聚糖酸盐对控释性的影响很少。因此，本研究的目的是基于三种典型的酸三种壳聚糖水凝胶，广泛用作壳聚糖的溶剂，通过SEM观察它们的形态和结构，并研究酸盐对溶胀行为和控制释放的影响壳聚糖水凝胶在模拟牙周袋环境中使用四环素HCL广泛应用于模型药物的牙周炎治疗。

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