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Optical Methods for the analysis of dermatopharmacokinetics

机译：Dermatopharmocokinetics分析的光学方法

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The method of tape stripping in combination with spectroscopic measurements is a simple and noninvasive method for the analysis of dermatopharmacokinetics of cosmetic products and topically applied drugs. The absorbance at 430 nm was used for the characterization of the amount of corneocytes on the tape strips. It was compared to the increase of weight of the tapes after removing them from the skin surface. The penetration profiles of two UV filter substances used in sunscreens were determined. The combined method of tape stripping and spectroscopic measurements can be also used for the investigation of the dermatopharmacokinetics of topically applied drugs passing through the skin. Differences in the penetration profiles of the steroid compound clobetasol, applied in the same concentration in different formulations on the skin are presented.
机译：与光谱测量组合的胶带剥离方法是用于分析化妆品和局部应用药物的Dermatopharmopopokinetics的简单而无侵入的方法。 430nm处的吸光度用于表征胶带条上的玉米粒细胞量。将其与皮肤表面除去后的胶带重量的增加进行了比较。确定了过阳囊中使用的两种UV过滤物质的渗透谱。胶带剥离和光谱测量的组合方法也可用于调查局部施加通过皮肤的局部应用药物的Dermatopharmocokinetics。呈现了在皮肤上不同配方中相同浓度施加的类固醇化合物的渗透谱的差异。

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