Synthesis of Fluorinated Prolines and Pyroglutamic Acids

机译：氟化脯氨酸和焦蛋白酸的合成

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Recent achievements in the synthesis of fluorinated prolines and pyroglutamic acids are described. 4(3)-Fluoroprolines and 4,4(3,3)-difluoroproIines were prepared by the fluorination of 4(3)-hydroxyprolines and 4(3)-ketoprolines respectively. 4-Trifluoromethyl- and 4-difluoromethylprolines were obtained starting from the fluorine-containing building blocks. The oxidation of fluorinated prolines provided fluorinated pyroglutamic acids.

机译：描述了最近在合成氟化脯氨酸和焦葡萄酒酸中的成就。通过分别氟化4（3） - 羟基脯氨酸和4（3）酮丙醇，制备4（3） - 氟丙烯啉和4,4（3,3） - 二氟丙酮。从含氟结构块开始获得4-三氟甲基和4-二氟甲基脯氨酸。氟化脯氨酸的氧化提供了氟化吡葡酸酸。

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《American Chemical Society Symposium on Fluorine-Containing Synthons》|2005年||共10页
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Feng-Ling Qing; Xiao-Long Qiu;
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中图分类基本有机化学工业;
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Synthesis of Fluorinated Prolines and Pyroglutamic Acids

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