Polio Vaccines, SV40 and Human Tumours, an Update on False Positive and False Negative Results

机译：脊髓灰质炎疫苗，SV40和人类肿瘤，更新假阳性和假阴性结果

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Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human tumours has been linked to the administration of SV40-contaminated polio vaccines from 1954 until 1963. Many of these reportslinked SV40 to human mesothelioma. Some studies have failed to detect SV40 in human tumours and this has caused a controversy. Here we review the current literature. Moreover, we present evidence showing how differences in the sensitivities of methodologies can lead to a very different interpretation of the same study. The same 20 mesothelioma specimens all tested negative, 2/20 tested positive or 7/20 tested positive for SV40 Tag by simply changing the detection method on the same immuno-pre-cipitation/western blot membranes. These results provide a simple explanation for some of the apparent discordant results reported in the literature.

机译：在许多实验室中，在不同的人类肿瘤中检测到Simian病毒40（SV40）。在1954年之前，人肿瘤中SV40的SV40检测与SV40污染的脊髓灰质炎疫苗一起联系在1963年之前。许多这些报告链接SV40对人间皮瘤。一些研究未能检测人类肿瘤中的SV40，这导致了争议。在这里，我们审查了当前的文献。此外，我们提出了证明方法敏感性的差异如何导致对同一研究的差异非常不同的解释。通过简单地改变在同一免疫预展示/蛋白质印迹膜上的检测方法，相同的20个MestoChiom标本，2/20测试阳性或7/20测试阳性的SV40标签。这些结果对文献中报告的一些明显的一种不和谐的结果提供了简单的解释。

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《Conference of the National Institutes of Health》|2006年||共9页
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AG. Elmishad; M. Bocchetta; H.I. Pass; M. Carbon;
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4. Polio Vaccines, SV40 and Human Tumours, an Update on False Positive and False Negative Results [C] . AG. Elmishad, M. Bocchetta, H.I. Pass, Conference of the National Institutes of Health . 2006

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Polio Vaccines, SV40 and Human Tumours, an Update on False Positive and False Negative Results

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