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首页> 外文会议>International Symposium on Energy and Protein Metabolism and Nutrition >Effect of inoculation with intestinal bacteria on intestinal gene expression in the interleukin-10 knockout mouse
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Effect of inoculation with intestinal bacteria on intestinal gene expression in the interleukin-10 knockout mouse

机译：肠道细菌接种对白细胞介素-10敲除小鼠肠道基因表达的影响

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The complex genetic nature of Inflammatory Bowel Diseases (IBD: Crohn Disease and Ulcerative Colitis), and the interaction between food, host genetic background and resident intestinal bacteria, means that animal models of IBD are essential to study these interactions. The interleukin-10 knockout (IL10) mouse has been reported to spontaneously develop Crohn Disease-like intestinal enterocolitis, caused in part by an inappropriate response to normal intestinal bacteria, when raised under conventionalconditions, and has been used extensively as a model of IBD (Jurjus et al., 2004). In a previous study, we found that intestinal inflammation in IL10 mice (C57BL/6J background) was not significantly higher than in C57BL/6 (control) mice due to a high variability of response between IL10 mice (Barnett et al., unpublished data). Our aim was to test whether an oral inoculation of IL10 mice with normal intestinal bacteria would result in a more consistent intestinal inflammation and to characterise gene expression changes in intestinal cells resulting from this inoculation.
机译：炎症性肠病疾病（IBD：Crohn病和溃疡性结肠炎）的复杂遗传性质，以及食物，宿主遗传背景和常规肠道细菌之间的相互作用意味着IBD的动物模型对于研究这些相互作用至关重要。据报道，白细胞介素-10敲除（IL10）小鼠自发地发展CROHN病如肠道肠凝集症，部分因在常规条件下提出的正常肠道细菌的不恰当响应而导致，并且已被广泛使用作为IBD的模型（ jurjus等人。，2004）。在先前的研究中，我们发现IL10小鼠（C57BL / 6J背景）中的肠炎症由于IL10小鼠之间的响应的高变异性而显着高于C57BL / 6（对照）小鼠（Barnett等人，未发表的数据）。我们的目的是测试患有正常肠细菌的IL10小鼠的口服接种是否会导致更一致的肠炎症，并表征由这种接种引起的肠细胞的基因表达变化。

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