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首页> 外文会议>British Mycological Society. Symposium >The biosynthesis of polyketides, acyl tetramic acids and pyridones by filamentous fungi
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The biosynthesis of polyketides, acyl tetramic acids and pyridones by filamentous fungi

机译：聚酮基，酰基四酰胺和吡啶酮的生物合成通过丝状真菌

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The filamentous fungi are proficient and copious producers of secondary metabolites,. From the perspective of an organic chemist, the range and variety of chemical structures of these compounds is remarkable. Synthetic organic chemists have often used the very high structural complexity of fungal secondary metabolites to test their own abilities to mimic nature,. From the perspective of a medicinal chemist, the diversity of compounds and structural types represents a pool of useful compounds often possessing unique biological properties. The range of structural types can, at first, appear baffling,. However, most secondary metabolites produced by fungi fall into a relatively small number of classes: the alkaloids, derived from amines and amino acids; the terpenoids, derived from isopentenyl diphosphate; and the polyketides, generally derived from acetate,. This system of classification is based on the biosynthetic origin of the compound in question, that is to say, a combination of the type of starting material and the type of chemical reactions used during biosynthesis,. However, fungi also often combine different types of biosynthetic pathway during the manufacture of secondary metabolites. In Bristol, we have focused our efforts on understanding the biosynthesis of polyketides in fungi, but the inclusion of amino-acid derived moieties in the compounds we are interested in has also necessitated wider investigations.
机译：丝状真菌是精通和大量的次级代谢物生产商，。从有机化学家的角度来看，这些化合物的化学结构的范围和各种是显着的。合成有机化学剂经常使用真菌次级代谢物的非常高的结构复杂性，以测试它们自身的模仿性质的能力。从药用化学家的角度来看，化合物和结构类型的多样性代表了一种通常具有独特的生物特性的有用化合物的池。首先，结构类型的范围显得令人困惑，。然而，由真菌产生的大多数次生代谢物落入相对少量的阶级：来自胺和氨基酸的生物碱;衍生自异戊二烯基二磷酸的三萜胶;和聚酮，通常衍生自乙酸盐，。该分类系统基于所讨论的化合物的生物合成来源，也就是说，原料类型的组合和生物合成期间使用的化学反应的类型。然而，在次级代谢物的制备过程中，真菌还经常结合不同类型的生物合成途径。在布里斯托尔，我们致力于了解真菌中聚酮化合物的生物合成，但在我们感兴趣的化合物中包含氨基酸衍生的部分也需要更广泛的调查。

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