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首页> 外文会议>IASTED international conference on nanotechnology and applications >SINGLE PARTICLE COUNTER USING NANOPORES: MULTIPHYSICS SIMULATIONS AND EXPERIMENTS
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SINGLE PARTICLE COUNTER USING NANOPORES: MULTIPHYSICS SIMULATIONS AND EXPERIMENTS

机译：单粒子计数器使用纳米孔：多体仿真和实验

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Investigations on micro-fabricated devices for biomedical applications such as biosensors have swiftly advanced in the last few years. The suitability of these devices for such applications has been extensively documented by universities and private laboratories alike. Detection of single molecules is fundamental for enhancing our understanding of delicate biological mechanisms. This would open new promising areas in diagnostics and therapeutics. This paper discusses the simulations and experiments carried out on electric field-induced translocation of polystyrene beads through silicon nitride nanopores. The behavior of the spherical particles suspended in the electrolyte solution to the applied electric field is studied. The use of focusing electrode to focus the charged particles into the centre of the chamber is also discussed. The electric field, the ionic current though the pore, and the translocation time are computed using Femlab simulations and later verified experimentally.
机译：在过去几年中，生物医学应用的微制造装置的研究迅速推进。这些设备的适用性已被大学和私人实验室广泛记录。单个分子的检测是提高我们对精致生物机制的理解的基础。这将在诊断和治疗中开放新的有希望的领域。本文讨论了通过氮化硅纳米孔的电场诱导的聚苯乙烯珠粒易位进行的模拟和实验。研究了悬浮在电解质溶液中的球形颗粒的行为。还讨论了将聚焦电极聚焦到腔室中心的带电粒子。电场，离子电流虽然孔，以及使用Femlab模拟计算的易位时间，并在实验上验证。

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