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首页> 外文会议>Nanotechnology amp; applications >SINGLE PARTICLE COUNTER USING NANOPORES: MULTIPHYSICS SIMULATIONS AND EXPERIMENTS
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SINGLE PARTICLE COUNTER USING NANOPORES: MULTIPHYSICS SIMULATIONS AND EXPERIMENTS

机译：使用纳米孔的单粒子计数器：多物理场模拟和实验

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摘要

Investigations on micro-fabricated devices for biomedical applications such as biosensors have swiftly advanced in the last few years. The suitability of these devices for such applications has been extensively documented by universities and private laboratories alike. Detection of single molecules is fundamental for enhancing our understanding of delicate biological mechanisms. This would open new promising areas in diagnostics and therapeutics. This paper discusses the simulations and experiments carried out on electric field-induced translocation of polystyrene beads through silicon nitride nanopores. The behavior of the spherical particles suspended in the electrolyte solution to the applied electric field is studied. The use of focusing electrode to focus the charged particles into the centre of the chamber is also discussed. The electric field, the ionic current though the pore, and the translocation time are computed using Femlab simulations and later verified experimentally.
机译：在过去几年中，对用于生物医学应用的微型制造设备（例如生物传感器）的研究迅速发展。这些设备在此类应用中的适用性已被大学和私人实验室广泛记录。检测单个分子是增强我们对精细生物学机制的理解的基础。这将在诊断和治疗领域开辟新的有希望的领域。本文讨论了模拟和实验的电场诱导聚苯乙烯珠通过氮化硅纳米孔易位。研究了悬浮在电解质溶液中的球形颗粒对施加电场的行为。还讨论了使用聚焦电极将带电粒子聚焦到腔室的中心。使用Femlab模拟计算电场，通过孔的离子电流和迁移时间，然后通过实验进行验证。

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  • 来源
  • 会议地点 Crete(GR);Crete(GR)
  • 作者

    H. V. B. Achar; M. Rossi; S. Cavalcanti; E. Giordano; E. Sangiorgi; M. Tartagni;

  • 作者单位

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy Department of Electrical Engineering, Indian Institute of Technology Madras, Chennai, India;

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy Silicon Biosystems S.p.A., Bologna, Italy;

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy;

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy;

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy;

    ARCES, II Facolta di Ingegneria, Universita di Bologna, Sede di Cesena, Cesena, Italy;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    biosensors; nanopores; coulter counters; multiphysics simulations;

    机译：生物传感器纳米孔犁刀柜台多物理场模拟;

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