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首页> 外文会议>Annual World Conference on Carbon >Chromatographic Separation of Highly Soluble Nanodiamond Prepared by Polyglycerol Grafting
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Chromatographic Separation of Highly Soluble Nanodiamond Prepared by Polyglycerol Grafting

机译：聚甘油嫁接制备高度可溶性纳米金刚石的色谱分离

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Biomedical applications of nanodiamond (ND) have been investigated extensively due to its low toxicity, non-bleaching fluorescence and high extensibility of the surface functionality through covalent organic functionalization. For the purpose, ND should first form a stable hydrosol under a physiological environment. In order to increase the solubility, we change the surface functionality of ND from conventional linear polyethers (PEG) [1] to hyperbranched polyglycerols (PG) (Scheme 1). We choose the PG functionality for the following reasons: high hydrophilic property, biocompatibility, hyperbranched structure and easy functionalization. As a result, the PG grafted ND (ND-PG) exhibited extremely high solubility (16 mg/mL) in phosphate buffer saline (PBS) [2].
机译：通过其低毒性，非漂白荧光和通过共价有机官能化的表面官能团的高伸展性，已经广泛地研究了纳米金刚胺（ND）的生物医学应用。为目的，ND应首先在生理环境下形成稳定的水溶酚。为了提高溶解度，我们将Nd的表面功能从常规的直链聚醚（PEG）[1]改变为超支化聚甘油（PG）（方案1）。我们选择PG功能，原因如下：高亲水性，生物相容性，超支化结构和易于官能化。结果，PG接枝Nd（ND-PG）在磷酸盐缓冲盐（PBS）中表现出极高的溶解度（16mg / ml）[2]。

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