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Preclinical surrogate models of spontaneous pain: an opportunity for drug development in neuropathic pain

机译：自发性疼痛的临床前替代模型：神经性疼痛中药物发育的机会

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Neuropathic pain still is a challenging health problem: it can affect up to 7% of the population, and only a few medications are currently available for its treatment. Although evoked pain (hyperalgesia and allodynia) are important clinical phenomena, the main complaint of patients with neuropathic pain is spontaneous pain. Strikingly, however, investigation of neuropathic suffers from the lack of an objective biological marker of the intensity of pain. For this reason, pain intensity assessment in humans is still based on verbal communication or psychophysical pain scales. The situation is aggravated by the concomitant lack of validated, reliable preclinical surrogate models of spontaneous pain. The majority of available preclinical models of neuropathic pain are behavioral models of evoked pain in which measures of mechanical and thermal hypersensitivity are obtained using calibrated filaments and thermal stimulators. These preclinical models may represent models for the clinical phenomena of hyperalgesia and allodynia, but not of spontaneous pains.
机译：神经性疼痛仍然是一个有挑战性的健康问题：它可能影响占人口的7％，目前只有几种药物可用于其治疗。虽然诱发疼痛（痛觉过敏性和异常性疼痛）是重要的临床现象，但神经性疼痛患者的主要抱怨是自发的疼痛。然而，令人惊讶的是，对神经病变的调查患有疼痛强度的客观生物学标记。因此，人类的疼痛强度评估仍然基于口头通信或心理物理疼痛尺度。伴随着缺乏验证，可靠的自发性疼痛的可靠临床前替代模型加剧了这种情况。大多数可用的神经病疼痛模型是诱发疼痛的行为模型，其中使用校准的长丝和热刺激器获得机械和热超敏的测量。这些临床前模型可以代表痛觉过敏性和异常性的临床现象的模型，但不是自发痛苦。

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