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首页> 外文会议>SPIE Conference on Plasmonics in Biology and Medicine >Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing
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Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing

机译：作为分子和生物传感的整体多孔金纳序作为表面增强拉曼光谱底物

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Surface-enhanced Raman spectroscopy (SERS) has been widely used for high-sensitivity molecular detection and identification. It is advantageous for a SERS substrate to have a large surface-to-volume ratio from the standpoint of high density "hot spots" and optical sampling efficiency. In this paper, we show that monolithic porous gold nanostructures such as nanofilms and nanodisks can be effective SERS substrates with large surface area. The average enhancement factor of the nanodisk and nanofilm substrates have been determined using benzenethiol self-assembled monolayers to be ~100 million and 0.5 million, respectively. Variability on the order of 40% has been observed by large area SERS mapping. A single nanodisk coated with benzenethiol self-assembled monolayer (~10 attmoles) can provide SERS spectrum with a signal-to-noise ratio ~400, resulting in an estimated detection limit in the range of zeptomoles.
机译：表面增强拉曼光谱（SERS）已广泛用于高灵敏度分子检测和鉴定。从高密度“热点”和光学采样效率的观点来看，SERS基板具有大的表面到体积比具有大的表面到体积比。在本文中，我们表明单片多孔金纳米结构如纳米螺纹和纳米管，可以是具有大表面积的有效的SERS基材。使用苯硫醇自组装单层测定纳米型敏感和纳米丝基板的平均增强因子分别为约1亿和0.5百万。大面积SERS映射观察到约为40％的可变性。涂有苯硫醇自组装单层（〜10 attmoles）的单一纳米型敏感型可以提供具有信噪比〜400的SERS光谱，导致Zeptomoles范围内的估计检测限。

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