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首页> 外文会议>Plasmonics in biology and medicine X >Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing
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Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing

机译：整体多孔金纳米结构作为表面增强拉曼光谱的基底，用于分子和生物传感

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Surface-enhanced Raman spectroscopy (SERS) has been widely used for high-sensitivity molecular detection and identification. It is advantageous for a SERS substrate to have a large surface-to-volume ratio from the standpoint of high density "hot spots" and optical sampling efficiency. In this paper, we show that monolithic porous gold nanostructures such as nanofilms and nanodisks can be effective SERS substrates with large surface area. The average enhancement factor of the nanodisk and nanofilm substrates have been determined using benzenethiol self-assembled monolayers to be ～100 million and 0.5 million, respectively. Variability on the order of 40% has been observed by large area SERS mapping. A single nanodisk coated with benzenethiol self-assembled monolayer (～10 attmoles) can provide SERS spectrum with a signal-to-noise ratio ～400, resulting in an estimated detection limit in the range of zeptomoles.
机译：表面增强拉曼光谱（SERS）已被广泛用于高灵敏度分子检测和鉴定。从高密度“热点”和光学采样效率的观点来看，SERS衬底具有大的表面体积比是有利的。在本文中，我们表明整体式多孔金纳米结构（例如纳米膜和纳米盘）可以是有效的大表面积SERS衬底。使用苯硫醇自组装单层测定的纳米盘和纳米膜基质的平均增强因子分别为约1亿和50万。通过大面积SERS映射已观察到40％左右的变异性。涂有苯硫醇自组装单分子膜（约10 attmol）的单个纳米盘可以提供SERS光谱，信噪比约400，从而导致估计的检出限在七分子范围内。

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