Study on Biological Materials with Facile Synthesis and Anti-breast Cancer Activities of Hydroxylchalcones Derivatives

机译：羟基醌衍生物的抗乳腺癌活性生物材料研究

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Hydroxylchalcone are known to act on various physiological targets. In this study, a series of nine hydroxychalcones were synthesized via the aldol condensation with the aim of obtaining bioactive small molecules. Their structures were characterized by NMR spectra. The anti-breast cancer activity evaluation indicated the monohydroxychalcones exhibited the better anti-proliferative effect than dihydroxylchalcones against MDA-MB-231 cells, and the compound 3b showed the best anti-breast cancer activities at 18 μM. The bioactive compounds might be used to develop as potential anti-breast cancer agents.

机译：已知羟基缩略酮作用于各种生理靶标。在该研究中，通过醛醇缩合合成了一系列九种羟基羟烷基，目的是获得生物活性小分子。它们的结构以NMR光谱为特征。抗乳腺癌活性评价表明单羟基妥核酮表现出比对MDA-MB-231细胞的二羟基凝块更好的抗增殖作用，化合物3B在18μm下显示最佳的抗乳腺癌活动。生物活性化合物可用于发展为潜在的抗乳腺癌剂。

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《International Conference on Material Engineering, Chemistry, Bioinformatics》|2014年||共4页
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作者
JIANG Kun; DONG Xinfei; LU Xiaofeng; WANG Junzhi; ZOU Kun; HUANG Nianyu;
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中图分类 TB3-53;
关键词
Hydroxylchalcone; Anti-breast cancer activity; Synthesis; Structure elucidation;

机译：羟基醌;抗乳腺癌活动;合成;结构阐明;

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Study on Biological Materials with Facile Synthesis and Anti-breast Cancer Activities of Hydroxylchalcones Derivatives

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