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首页> 外文会议>International Conference on Medical Physiology >Studies of doped biomimetic nano-hydroxyapatite/polymer matrix Composites for applications in biomedical field
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Studies of doped biomimetic nano-hydroxyapatite/polymer matrix Composites for applications in biomedical field

机译：掺杂仿生纳米羟基磷灰石/聚合物基复合材料在生物医学领域应用

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Every year, millions of people are suffering from bone defect arising from trauma, tumor or bone diseases. Therefore, there is a growing need for the development of biocomposites with excellent bioactivity and compatibility. In this study, nano-hydroxyapatite was elaborated by using polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) under mild temperature condition. Comparison with pure nano-hydroxyapatite prepared by precipitation method was investigated. The main goal is to highlight the effects of the introduction of polymers on the physico-chemical properties, morphology and on the chemical reactivity and bioactivity for applications in bony surgery. TEM showed a nanosphere hydroxyapatite with an average diameter 45 nm obtained by using PVA. Nano-rods HA with an average dimensions 13 nm width and 156 nm length were obtained by using, PVP. "In-vitro" physiological stability and solubility of the investigated samples was performed by soaking powder in Simulated Body Fluid under physiological condition. Characterization by XRD, FT-IR SEM-EDS and ICP-OES were performed to identify phases, microstructure and then the chemical reactivity and bioactivity after soaking in SBF to evaluate the bioactivity kinetics. Crystals on the polymer fibril matrix exhibited certain orientation. Bone like apatite layer onto the surfaces is confirmed after post immersion in SBF by FT-IR, SEM-EDS and XRD. The polymer matrix controlled the dissolution precipitation reactivity with specific rate without change on the pH of the surrounding physiological body fluid.
机译：每年，数百万人患有来自创伤，肿瘤或骨病产生的骨缺损。因此，越来越需要发展生物复合材料，具有优异的生物复合性和相容性。在该研究中，通过使用温度温度条件下使用聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）来阐述纳米羟基磷灰石。研究了与沉淀法制备的纯纳米磷灰石的比较。主要目标是突出聚合物引入对物理化学性质，形态和化学反应性和生物活性的影响，在骨手术中的应用。 TEM显示纳米羟基磷灰石，通过使用PVA获得平均直径45nm。通过使用PVP获得平均尺寸的纳米棒HA宽度为13nm宽度和156nm长度。通过在生理条件下浸泡粉末在模拟体液中浸泡粉末进行研究的生理稳定性和溶解度。通过XRD，FT-IR SEM-EDS和ICP-OES进行表征以鉴定阶段，微观结构，然后在SBF浸泡后进行化学反应性和生物活性，以评估生物活性动力学。聚合物原纤维基质上的晶体表现出某些取向。通过FT-IR，SEM-EDS和XRD在SBF中浸入后，确认在表面上的惰性层。聚合物基质控制溶解沉淀反应性，特定速率而不改变周围的生理体液的pH。

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