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首页> 外文会议>Recent researches in modern medicine >Studies of doped biomimetic nano-hydroxyapatite/polymer matrix Composites for applications in biomedical field
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Studies of doped biomimetic nano-hydroxyapatite/polymer matrix Composites for applications in biomedical field

机译：掺杂仿生纳米羟基磷灰石/聚合物基复合材料在生物医学领域的应用研究

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Every year, millions of people are suffering from bone defect arising from trauma, tumor or bone diseases. Therefore, there is a growing need for the development of biocomposites with excellent bioactivity and compatibility. . In this study, nano-hydroxyapatite was elaborated by using polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) under mild temperature condition. Comparison with pure nano-hydroxyapatite prepared by precipitation method was investigated. The main goal is to highlight the effects of the introduction of polymers on the physico-chemical properties, morphology and on the chemical reactivity and bioactivity for applications in bony surgery. TEM showed a nanosphere hydroxyapatite with an average diameter 45 nm obtained by using PVA. Nano-rods HA with an average dimensions 13 nm width and 156 nm length were obtained by using, PVP. "In-vitro" physiological stability and solubility of the investigated samples was performed by soaking powder in Simulated Body Fluid under physiological condition. Characterization by XRD, FT-IR SEM-EDS and ICP-OES were performed to identify phases, micro structure and then the chemical reactivity and bioactivity after soaking in SBF to evaluate the bioactivity kinetics. Crystals on the polymer fibril matrix exhibited certain orientation. Bone like apatite layer onto the surfaces is confirmed after post immersion in SBF by FT-IR, SEM-EDS and XRD. The polymer matrix controlled the dissolution precipitation reactivity with specific rate without change on the pH of the surrounding physiological body fluid.
机译：每年，数百万人正遭受由外伤，肿瘤或骨骼疾病引起的骨骼缺陷。因此，越来越需要开发具有优异的生物活性和相容性的生物复合材料。 。在这项研究中，通过在温和的温度条件下使用聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）来制备纳米羟基磷灰石。研究了与沉淀法制备的纯纳米羟基磷灰石的比较。主要目的是强调聚合物的引入对骨外科应用的理化性质，形态以及化学反应性和生物活性的影响。 TEM显示通过使用PVA获得的平均直径为45nm的纳米球羟基磷灰石。通过使用PVP获得平均尺寸为13nm宽和156nm长的纳米棒HA。通过在生理条件下将粉末浸泡在模拟体液中来进行研究样品的“体外”生理稳定性和溶解性。通过XRD，FT-IR SEM-EDS和ICP-OES进行表征，以鉴定相，微观结构，然后浸泡在SBF中以鉴定化学活性和生物活性，以评估生物活性动力学。聚合物原纤维基质上的晶体表现出一定的取向。在通过FT-IR，SEM-EDS和XRD后浸泡在SBF中后，可以确认表面上的骨状磷灰石层。聚合物基质以特定速率控制溶解沉淀反应性，而不会改变周围生理体液的pH。

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