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首页> 外文会议>International Conference on Medical Physiology >Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres
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Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres

机译：来自生物可吸收聚（酯 - 醚酯）微球的抗癌药物紫杉醇的控制释放

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摘要

The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(ε-caprolactone-oxyethylene-ε-caprolactone) tri-block copolymer was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, M_t/M_x = k · t~n, where M_t is the amount of solute released at the time t, M_x is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
机译：研究了来自生物可吸收多（ε-己内酯 - 氧乙烯-ε-己内酯）三嵌段共聚物的微球的抗癌药物紫杉醇（PTX）的释放。通过乳液蒸发技术制备负载且不具有PTX的微球，然后通过SEM，AFM，全反射和聚光灯FT-IR光谱和DSC表征。通过HPLC测量释放的PTX的量。结果表明慢性且非常普通的释放，这很易于PEPPAS方程，M_T / M_X = k·t〜N，其中M_T是在时间t释放的溶质量，M_X是在释放的药物量平台条件，K代表Peppas动力量常数和n扩散序列。

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