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首页> 外文会议>Recent researches in modern medicine >Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly (ester-ether-ester) Microspheres
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Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly (ester-ether-ester) Microspheres

机译：从生物可吸收的聚（酯-醚-酯）微球中控制释放抗癌药物紫杉醇

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摘要

The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(ε-caprolactone-oxyethylene-e-caprolactone) tri-block copolymer was studied. The microspheres, both loaded and nol with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, M/M-f. = k-t~n, where M, is the amount of solute released at the time r, M_x is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
机译：研究了抗癌药物紫杉醇（PTX）从可生物吸收的聚（ε-己内酯-氧乙烯-e-己内酯）三嵌段共聚物的微球中的释放。通过乳液蒸发技术制备了载有PTX和没有PTX的微球，然后通过SEM，AFM，全反射和聚光FT-IR光谱以及DSC对其进行了表征。通过HPLC测量释放的PTX的量。结果显示释放缓慢且非常规则，非常符合Peppas方程M / M-f。 ＝ k-t〜n，其中M是在时间r释放的溶质的量，M_x是在平台状态下释放的药物的量，k表示Peppas动力学常数，n表示扩散阶数。

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  • 来源
    《Recent researches in modern medicine》|2011年|p.210-217|共8页
  • 会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
  • 作者

    G. D. GUERRA; M. GAGLIARDI; N. BARBANI; C. CRISTALLINI;

  • 作者单位

    Institute for Biomedical and Composite Materials, U.O.S. of Pisa ,Largo Lucio Lazzarino, 1-56122 Pisa ITALY;

    Department of Chemical Engineering 'Italian National Research Council (CNR), University of Pisa,Largo Lucio Lazzarino, 1-56122 Pisa ITALY;

    Department of Chemical Engineering 'Italian National Research Council (CNR), University of Pisa,Largo Lucio Lazzarino, 1-56122 Pisa ITALY;

    Institute for Biomedical and Composite Materials, U.O.S. of Pisa ,Largo Lucio Lazzarino, 1-56122 Pisa ITALY;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    poly(ester-ether-ester); paclitaxel; microspheres; bioresorbable material; characterization; controlled release;

    机译：聚（酯-醚-酯）;紫杉醇微球生物可吸收材料表征;控释;

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