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首页> 外文会议>SPIE Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Carbon Nanotube Based Respiratory Gated Micro-CT Imaging of aMurine Model of Lung Tumors with Optical Imaging Correlation
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Carbon Nanotube Based Respiratory Gated Micro-CT Imaging of aMurine Model of Lung Tumors with Optical Imaging Correlation

机译：光学成像关联的碳纳米管基呼吸呼吸门微型CT成像肺肿瘤的肺肿瘤模型

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Current optical imaging techniques can successfully measure tumor load in murine models of lung carcinoma but lack structural detail. We demonstrate that respiratory gated micro-CT imaging of such models gives information about structure and correlates with tumor load measurements by optical methods. Four mice with multifocal, Kras-induced tumors expressing firefly luciferase were imaged against four controls using both optical imaging and respiratory gated micro-CT. CT images of anesthetized animals were acquired with a custom CNT-based system using 30 ms x-ray pulses during peak inspiration; respiration motion was tracked with a pressure sensor beneath each animal's abdomen. Optical imaging based on the Luc+ signal correlating with tumor load was performed on a Xenogen IVIS Kinetix. Micro-CT images were post-processed using Osirix, measuring lung volume with region growing. Diameters of the largest three tumors were measured. Relationships between tumor size, lung volumes, and optical signal were compared. CT images and optical signals were obtained for all animals at two time points. In all lobes of the Kras+ mice in all images, tumors were visible; the smallest to be readily identified measured approximately 300 microns diameter. CT-derived tumor volumes and optical signals related linearly, with r=0.89 for all animals. When derived for only tumor bearing animals, r=0.3. The trend of each individual animal's optical signal tracked correctly based on the CT volumes. Interestingly, lung volumes also correlated positively with optical imaging data and tumor volume burden, suggesting active remodeling.
机译：目前的光学成像技术可以成功测量肺癌鼠模型的肿瘤载荷，但缺乏结构细节。我们证明这种模型的呼吸门控微型CT成像提供了有关结构的信息，并通过光学方法与肿瘤载荷测量相关。使用多焦点的多焦点的小鼠诱导表达萤火虫荧光素酶的肿瘤，其使用光学成像和呼吸门的微型CT对4个对照进行成像。在峰值吸气期间，使用30ms X射线脉冲的基于CNT的基于CNT的系统获得了麻醉动物的CT图像;在每个动物腹部下方用压力传感器跟踪呼吸运动。基于Luc +信号与肿瘤载荷相关的光学成像在鼻嘌呤Ivis Kinetix上进行。使用Osirix进行微型CT图像，测量具有区域生长的肺体积。测量了最大的三种肿瘤的直径。比较肿瘤大小，肺量和光学信号之间的关系。在两个时间点的所有动物获得CT图像和光学信号。在所有图像中KRAS +小鼠的所有裂片中，肿瘤可见;最小的易于识别测量约300微米直径。 CT衍生的肿瘤体积和光学信号线性相关，所有动物的r = 0.89。当仅用于肿瘤轴承动物时，r = 0.3。基于CT卷正确跟踪每个单独动物的光信号的趋势。有趣的是，肺量也与光学成像数据和肿瘤体积负担正相关，表明有源重塑。

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