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首页> 外文会议>International Conference on Biomedical and Biological Engineering >Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to TNF-α, IL-6 of IgA Nephropathy Model Rat
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Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to TNF-α, IL-6 of IgA Nephropathy Model Rat

机译：调整肾脏和脾，咽喉法解毒对IGA肾病模型大鼠TNF-α，IL-6的影响

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Purpose: To study the effect and function mechanism of Tonifying Kidney and Spleen, Detoxification of Throat method on IgA nephropathy. Methods: the 72 Wistar rats were randomly divided into blank group, model group, Lotensin group, Tonifying kidney and spleen, detoxification of throat high, medium and low dose group (which is called traditional Chinese medicine high, medium and low dose group for short). The IgA nephropathy rat model were established by the method of feeding with bovine serum albumin (BSA) and injecting tail vein with lipopolysaccharide (LPS). After Eight weeks administration, each phase's urine red blood cell count, 24h UTP, TNF-α and IL-6 content were observed. Results: compared with model group, every groups' UTP decreased and TCM medium dose group decreased extraordinary (P<0.05); compared with model group, urine red blood cell count decreased significantly of every TCM group (P<0.05), especially TCM medium dose group improved significantly (P<0.01), but Lotensin group urine red blood cell count no drop (P>0.05); compared with blank group, TNF-α, IL-6 of model group's were significantly elevated (P<0.05); compared with model group, TNF-α, IL-6 of treatment groups decreased significantly (P<0.05), compared between TCM group, TCM medium dose group's data is the most significant (P<0.01). Conclusion: Tonifying kidney and spleen, detoxification of throat method can reduce hematuria and proteinuria of IgA nephropathy model rats, and reduce the content of IL-6 and TNF-α in serum which is better than Lotensin.
机译：目的：研究调整肾脏和脾脏的效果和功能机制，咽喉咽喉咽部法解毒。方法：将72只Wistar大鼠随机分为空白组，模型组，莲素组，调整肾脏和脾脏，喉咙辐射，中低剂量组（其称为中药高，中低剂量组短）。通过用牛血清白蛋白（BSA）的方法和用脂多糖（LPS）注入尾静脉的方法建立IgA肾病大鼠模型。八周给药后，观察到每种阶段的尿红细胞计数，24HUTP，TNF-α和IL-6含量。结果：与模型组相比，每个群体的UTP减少和中医培养基剂量组的特异性（P <0.05）;与模型组相比，尿红细胞计数明显减少了每个TCM组（P <0.05），特别是中毒培养基剂量组显着改善（P <0.01），但莲素群尿红细胞计数无滴（P> 0.05） ;与空白组相比，模型组的TNF-α，IL-6显着升高（P <0.05）;与模型组相比，治疗组的IL-6显着下降（P <0.05），在TCM组之间比较，中医培养基剂量组的数据是最显着的（P <0.01）。结论：调整肾脏和脾脏，咽喉解毒可以减少IGA肾病模型大鼠的血尿和蛋白尿，降低血清中IL-6和TNF-α的含量，比藏素更好。

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