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首页> 外文会议>IMEKOFOODS Conference >A FLEXIBLE MODEL FOR THE DEVELOPMENT AND VALIDATION OF MULTIANALYTE METHODS FOR THE DETERMINATION OF MIGRANTS FROM FOOD CONTACT MATERIALS
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A FLEXIBLE MODEL FOR THE DEVELOPMENT AND VALIDATION OF MULTIANALYTE METHODS FOR THE DETERMINATION OF MIGRANTS FROM FOOD CONTACT MATERIALS

机译：一种柔性模型，用于多重纳米纳利方法测定食品接触材料的多重方法

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Several thousands of chemical substances which are used in the production of food contact materials and articles have the potential to migrate into foods. It needs high analytical experience, hard work and high level instrumentation to determine the level of their migration into foods or food simulants. Development of multi-analyte methods is necessary in order to cope with the huge number of chemical compounds which should be determined. Application for the official control necessitates validation for each combination of analyte/substrate/simulant/migration condition. A very promising approach is based on the design and development of a structured flexible model for the establishment of modular analytical process which will incorporate the standard migration methods, different substrates in combination with various analytes and will include procedures for samples' preparation and instrumental analysis. The model foresees the extension to additional migrating compounds and food substrates followed by the necessary minimum validation actions in order to achieve a reliable result at the shortest time. The philosophy of this approach focuses on the breakdown of the analytical process into fully documented individual, independent and clearly defined stages (modules) which can be combined together to give the appropriate analytical process according to the target analyte(s) and simulants or food substrates. The implementation of this model provides a continuously expanding measurement capability of the laboratory with simultaneous satisfaction of the requirements for reliable, traceable and comparable results. This model is successfully applied to plastics' starting substances and additives, focusing on incorporation of the analysis of new plasticizers like diethylhexyl terephthalate using GC-FID and GC-MS instrumentation.
机译：用于生产食品接触材料和制品的数千种化学物质具有潜力迁移到食品中。它需要高分辨率的分析经验，努力工作和高级仪器，以确定其迁移水平的食物或食品模拟。为了应对应确定应确定的大量化合物是必要的多分析物方法的发展。官方控制申请需要验证分析物/衬底/模拟/迁移条件的每个组合。一种非常有前途的方法是基于用于建立模块化分析过程的结构化灵活模型的设计和开发，该过程将纳入标准迁移方法，与各种分析物组合的不同底物，并将包括样品制备和仪器分析的程序。该模型预计将延伸到额外的迁移化合物和食物基材，然后是必要的最低验证措施，以便在最短的时间内获得可靠的结果。该方法的哲学侧重于分析过程的分解为完全记录的个体，独立和明确的阶段（模块），其可以组合在一起，以提供根据靶分析物和模拟剂或食物基材的适当分析过程。该模型的实施提供了实验室的不断扩展的测量能力，同时满足了可靠，可追溯性和可比结果的要求。该模型成功应用于塑料的起始物质和添加剂，专注于使用GC-FID和GC-MS仪器掺入诸如对苯二甲酸二乙基己基的新增塑剂的分析。

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