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Spatial frequency domain imaging for monitoring palpable breast lesions

机译：用于监测可触及乳房病变的空间频域成像

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We describe a novel approach for monitoring breast lesions, utilizing spatial frequency domain imaging, a diffuse optical imaging method to detect hemoglobin contrast, in combination with mechanical compression of the tissue. The project is motivated by the growing rate of unnecessary breast biopsies, caused by uncertainty in X-ray mammographic diagnoses. We believe there is a need for an alternate means of tracking the progression palpable lesions exhibiting probably benign features, that can be performed non-invasively and hence frequently: at home or in the clinic. The proposed approach capitalizes on two distinguishing properties of cancerous lesions, namely the relative stiffness with respect to surrounding tissue and the optical absorption due to the greater vascularization, hence hemoglobin concentration. The current research project is a pilot study to evaluate the principle on soft, breast tissue-mimicking phantoms containing stiffer, more highly-absorbing inclusions. Spatial frequency domain imaging was performed by projecting onto the phantom a series of wide-field patterns at multiple spatial frequencies. Image analysis then was performed to map absorption and scattering properties. The results of the study demonstrate that compression significantly increases the optical contrast observed for inclusions located 10 and 15 mm beneath the surface. In the latter case, the inclusion was not detectable without compression.
机译：我们描述了一种用于监测乳房病变的新方法，利用空间域成像，漫反射光学成像方法来检测血红蛋白对比，与组织的机械压缩组合。该项目通过X射线乳房X线诊断的不确定性引起的不必要乳房活组织检查的增长。我们认为需要一种替代手段，可以跟踪展出可能良性特征的进展的术语，这可以是非侵入性的，因此经常进行：在家里或诊所。所提出的方法利用癌组织的两种显着性，即由于血管形成的血管形成而导致的周围组织和光学吸收的相对刚度。目前的研究项目是一种试点研究，以评估含有更静导体，更高吸收的夹杂物的软，乳房组织模拟的原理。通过在多个空间频率下突出到幻像上的幻像上的幻像一系列宽场模式来执行空间频域成像。然后进行图像分析以进行地图吸收和散射性能。该研究的结果表明，压缩显着地增加了位于表面下方10和15mm的夹杂物的光学对比度。在后一种情况下，在没有压缩的情况下，夹杂物不会检测到。

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