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首页> 外文会议>International Fundamentum Science Symposium >Dream over life: Psychedelic terphenyl derivative induce hallucination via cannabinoid receptor 1
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Dream over life: Psychedelic terphenyl derivative induce hallucination via cannabinoid receptor 1

机译：过度梦想：荧光三苯基衍生物通过大麻素受体1诱导幻觉1

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For ages, natural psychedelic resources have been used by ancient tribes for religious inspiration. In modern medicine, these compounds were prescribed to relieve severe distress and depression on cancer patients. Despite medical benefit, abuse of these compounds have become prevalent in our modern society. These compounds usually interacted with cannabinoid receptor 1 (CNRl)on neuron cell causing hallucination, and on other cell-types. In this study, chemically synthesized terphenyl derivative, 1,4-di(phenyl)benzene (13-BPB) interaction with human and its animal model were assessed. This derivative is an analogue found in fungi although their functional molecular mechanism is unknown. Terphenyl derivative known to have pharmacological activities-antifungal, anti-cancer, anticoagulant. Our study designed includes in-vitro assessment and in-silico model of 13-BPB interaction to the molecular mechanism in human and its animal model, mice. Cytotoxicity assessment using MTT has shown that treatment of 13BPB on NIH-3T3 and RAW 264.7 have significant reduction in cell viability at 0.016mM and 0.08inM, respectively. Virtual database screening based on homologous compounds identified possible interaction with 15 different proteins from receptors, enzymes and transcription factors, in human and mice. Further docking analysis shows terphenyl derivatives binding affinities (pKd/pKi) arc the highest with CNR1 and oestrogen receptors (ESRs).
机译：对于年龄来说，古代部落用于宗教启发的自然迷幻资源。在现代医学中，这些化合物被规定减轻癌症患者的严重痛苦和抑郁。尽管有医疗效益，但滥用这些化合物在我们现代社会中普遍存在。这些化合物通常在神经细胞上与大麻素受体1（CNRL）相互作用，导致幻觉和其他细胞类型。在该研究中，评估化学合成的三苯基衍生物，1,4-二（苯基）苯（13-BPB）与人及其动物模型的相互作用。这种衍生物是在真菌中发现的类似物，尽管它们的功能分子机制未知。已知具有药理学活性的三苯基衍生物 - 抗真菌，抗癌，抗凝血剂。我们的研究设计包括对13-BPB相互作用的体外评估和In-Silico型号，对人类及其动物模型的分子机制，小鼠。使用MTT的细胞毒性评估表明，在NIH-3T3和RAW 264.7上处理13bpb，分别在0.016mm和0.08inm的细胞活力下显着降低。基于同源化合物的虚拟数据库筛选鉴定了来自受体，酶和转录因子的15种不同蛋白质的可能相互作用，在人和小鼠中。进一步的对接分析显示三苯基衍生物结合亲和力（PKD / PKI）用CNR1和雌激素受体（ESRS）最高。

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