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首页> 外文会议>International Seminar on Smart Molecule of Natural Resources >The Effect of High Fat High Fructose Diet (Modification of AIN-93M) on Nuclear Factor Kappa Beta Expression in the Liver Tissue of Male Sprague Dawley Rats
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The Effect of High Fat High Fructose Diet (Modification of AIN-93M) on Nuclear Factor Kappa Beta Expression in the Liver Tissue of Male Sprague Dawley Rats

机译：高脂肪高果糖饮食（AIN-93M的改性）对雄性Sprague Dawley大鼠肝组织核因子Kappa表达的影响

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Metabolic inflammation (low-grade inflammation) remains an etiopathogenic key factor in the development of metabolic syndrome. Nuclear Factor Kappa Beta (NF-kβ) is a transcription regulator of genes having a role in immunity, the inflammatory response which can be associated with obesity-related pathological conditions like nonalcoholic fatty liver (NAFLD). Various stimuli, such as metabolic stress (hyperglycemia, ROS, fat metabolism) and proinflammatory cytokines (TNF-α, IL-6, IL-1β) could activate NF-kβ. This study was aimed to investigate the underlying molecular mechanisms of NAFLD in rats fed a modified AIN-93M HFHF (High Fat High Fructose) diet. The design of this study was experimental post-test only controlled group design. Thirty male Sprague Dawley rats were distributed into 2 treatment groups by a completely randomized design (CRD) technique. The sacrifice was performed after 17 weeks of treatment. NF-kβ expression was assessed by an immunohistochemical method (IRS score). The results showed there were significant differences in feed intake and energy intake between groups P1 and P2 (p = 0,000, p = 0,000). The average NF-kβ expression in the P2 group was significantly higher (p = 0.000) compared to the control group (P1). The correlation test between dietary intake and NF-kβ expression proved that there was a positive correlation between energy, carbohydrate and fat intake on NF-kβ expression (p = 0.001, 0.000, 0.046). However, there was a negative relationship between protein intake and NF-kβ expression (p = 0.000). This study concluded the modified AIN-93M HFHF diet increased NF-kβ expression in the liver tissue of male Sprague Dawley rats.
机译：代谢炎症（低级炎症）仍然是代谢综合征发展的病因致病性关键因素。核因子Kappaβ（NF-Kβ）是具有免疫作用的基因的转录调节因子，炎症反应可以与非酒精性脂肪肝（NAFLD）等肥胖相关的病理条件相关。各种刺激，例如代谢应激（高血糖，ROS，脂肪代谢）和促炎细胞因子（TNF-α，IL-6，IL-1β）可以激活NF-Kβ。本研究旨在探讨喂养改性AIN-93M HFHF（高脂肪高果糖）饮食的大鼠NAFLD的潜在分子机制。该研究的设计是实验后测试后的受控组设计。通过完全随机设计（CRD）技术将三十只雄性Sprague Dawley大鼠分配到2种治疗组中。牺牲在治疗17周后进行。通过免疫组织化学方法（IRS评分）评估NF-Kβ表达。结果表明，P1和P2组之间的进料摄入和能量摄入量存在显着差异（P = 0,000，P = 0,000）。与对照组相比，P2组的平均NF-kβ表达明显高（p = 0.000）（p1）。膳食摄入和NF-Kβ表达之间的相关试验证明，能量，碳水化合物和NF-Kβ表达上的脂肪摄入量之间存在正相关（P = 0.001,0.000,0.046）。然而，蛋白质摄入和NF-kβ表达之间存在负相关（p = 0.000）。该研究结束了修饰的AIN-93M HFHF饮食在雄性Sprague Dawley大鼠的肝组织中增加了NF-Kβ表达。

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