Antibacterial design based on the structures of gyrase-inhibitor complexes

机译：基于乙酶抑制剂络合物结构的抗菌设计

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The DNA topoisomerases are fascinating, ubiquitous, essential enzymes that perform remarkable contortions on DNA. There are two main classes, depending on the DNA substrate: the type I and type II topoisomerases, which operate on single-stranded and duplex DNA respectively. The type II topoisomerasea also differ in that they have a requirement for ATP. The reaction involves enzymatic cleavage of DNA (forming an enzyme/cleaved-DNA complex), the translocation of another portion of DNA through the break, followed by religation of the cleaved DNA.

机译：DNA拓扑异构酶是令人着迷的，普遍存在的，必需的酶，其在DNA上表现出显着的曲目。有两种主要类，取决于DNA底物：I型和II型拓扑酶，其分别在单链和双相DNA上操作。 II型Topoisomerasea也有所不同，因为它们需要ATP。反应涉及DNA的酶促切割（形成酶/切割-DNA复合物），通过断裂迁移DNA的另一部分，然后缩回切割的DNA。

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《NATO advanced study institute on experimental and computational approaches to structure-based drug design》|1998年||共16页
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Richard Pauptit; Simon Weston; Alex Breeze; Dean Derbyshire; Alec Tucker; Neil Hales; Dave Hollinshead; Dave Timms; NATO;
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中图分类药物基础科学;
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Antibacterial design based on the structures of gyrase-inhibitor complexes

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