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Current developments in clinical multiphoton tomography

机译：临床多光子层析成像的最新进展

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Two-photon microscopy has been introduced in 1990 [1]. 13 years later, CE-marked clinical multiphoton systems for 3D imaging of human skin with subcellular resolution have been launched by the JenLab company with the tomograph Dermalnspect~(TM). In 2010, the second generation of clinical multiphoton tomographs was introduced. The novel mobile multiphoton tomograph MPTflex~(TM), equipped with a flexible articulated optical arm, provides an increased flexibility and accessibility especially for clinical and cosmetical examinations. The multiphoton excitation of fluorescent biomolecules like NAD(P)H, flavins, porphyrins, elastin, and melanin as well as the second harmonic generation of collagen is induced by picojoule femtosecond laser pulses from an tunable turn-key near infrared laser system. The ability for rapid high-quality image acquisition, the user-friendly operation of the system, and the compact and flexible design qualifies this system to be used for melanoma detection, diagnostics of dermatological disorders, cosmetic research, and skin aging measurements as well as in situ drug monitoring and animal research. So far, more than 1,000 patients and volunteers have been investigated with the multiphoton tomographs in Europe, Asia, and Australia.
机译：1990年引入了双光子显微镜[1]。 13年后，JenLab公司通过X线断层扫描仪Dermalnspect〜（TM）推出了具有CE标志的具有亚细胞分辨率的3D人体皮肤3D成像临床多光子系统。 2010年，推出了第二代临床多光子断层扫描仪。配备有柔性铰接光学臂的新型移动式多光子断层扫描仪MPTflex〜提供了更大的灵活性和可及性，特别是对于临床和美容检查而言。皮焦耳飞秒飞秒激光脉冲通过可调谐交钥匙近红外激光系统诱发了荧光生物分子（如NAD（P）H，黄素，卟啉，弹性蛋白和黑色素）的多光子激发以及胶原的二次谐波生成。快速高质量图像采集的能力，系统的用户友好操作以及紧凑灵活的设计使该系统可用于黑色素瘤检测，皮肤病诊断，美容研究和皮肤衰老测量以及原位药物监测和动物研究。到目前为止，欧洲，亚洲和澳大利亚的多光子断层扫描仪已经对1,000多名患者和志愿者进行了调查。

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