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首页> 外文期刊>Journal of Biophotonics >Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases
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Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases

机译：皮肤疾病患者的临床光学相干断层扫描与多光子断层扫描相结合

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摘要

We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (ii) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface. OCT images reflect modifications of the intratissue refractive index whereas MPT is based on nonlinear excitation of endogenous fluorophores and second harmonic generation. A stack of cross-sectional OCT "wide field" images with a typical field of view of 5 × 2 mm~2 gave fast information on the depth and the volume of the lesion. Multiphoton tomography provided 0.36 × 0.36 mm~2 horizontal/diagonal optical sections within seconds of a particular region of interest with superior submicron resolution down to a Scheme of the multi-beam OCT
机译：我们报道了基于光学相干断层扫描（OCT）结合多光子断层扫描（MPT）和皮肤镜检查的第一项临床研究。已使用（i）先进的皮肤科OCT系统对47名患有多种皮肤疾病和疾病的患者进行了研究，这些疾病包括皮肤癌，牛皮癣，血管瘤，结缔组织疾病，色素沉着病变和自身免疫性大疱性皮肤病多束扫描源OCT，（ii）飞秒激光多光子断层扫描仪和（iii）皮肤镜。皮肤镜检查可提供皮肤表面的二维彩色图像。 OCT图像反映了组织内折射率的变化，而MPT基于内源性荧光团的非线性激发和二次谐波的产生。一叠典型的5×2 mm〜2视场的OCT横截面“宽视场”图像可快速显示病变的深度和体积。多光子断层扫描可在特定目标区域的秒内提供0.36×0.36 mm〜2的水平/对角光学截面，具有超亚微米分辨率，可降低至多光束OCT方案

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