Antibacterial design based on the structures of gyrase-inhibitor complexes

机译：基于回旋酶抑制剂复合物结构的抗菌设计

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The DNA topoisomerases are fascinating, ubiquitous, essential enzymes that perform remarkable contortions on DNA. There are two main classes, depending on the DNA substrate: the type I and type II topoisomerases, which operate on single-stranded and duplex DNA respectively. The type II topoisomerasea also differ in that they have a requirement for ATP. The reaction involves enzymatic cleavage of DNA (forming an enzyme/cleaved-DNA complex), the translocation of another portion of DNA through the break, followed by religation of the cleaved DNA.

机译：DNA拓扑异构酶是一种引人入胜的，普遍存在的必需酶，可对DNA产生明显的扭曲。取决于DNA底物，主要分为两类：I型和II型拓扑异构酶，它们分别作用于单链和双链DNA。 II型拓扑异构酶也不同，因为它们需要ATP。该反应涉及DNA的酶促裂解（形成酶/裂解的DNA复合物），DNA的另一部分通过断裂易位，然后裂解的DNA再连接。

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《NATO Advanced Study Institute on Experimental and Computational Approaches to Structure-Based Drug Design May 9-19, 1996 Erice, Sicily, Italy》|1996年|p.255-270|共16页
会议地点 Erice(IT)
作者
Richard Pauptit; Simon Weston; Alex Breeze; Dean Derbyshire; Alec Tucker; Neil Hales; Dave Hollinshead; Dave Timms;
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Antibacterial design based on the structures of gyrase-inhibitor complexes

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