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NMR Characterization and Product Design of Novel Silk-Based Biomaterials

机译：新型丝绸基生物材料的NMR表征和产品设计

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摘要

The atomic-level structure of the crystalline region of B. mori silk fibroin was studied using solid state NMR and statistical mechanical calculations. Whereas lamellar structures were proposed for both (AG)_(15) and (AGSGAG)_5 repetitive sequences of the crystalline region, the β-turn in (AGSGAG)_5 was found to be more distorted compared to that in (AG)_(15). In view of this structural information, silk-like mineralized composite materials were designed and characterized by solid state NMR. Furthermore, recombinant proteins were designed and produced in E. coli and transgenic silkworm. The films of these recombinant proteins exhibit high calcium binding activity and rapid mineralization.
机译：使用固态NMR和统计力学计算研究了桑蚕丝素蛋白晶体区域的原子级结构。尽管针对晶体区域的（AG）_（15）和（AGSGAG）_5重复序列都提出了层状结构，但发现（AGSGAG）_5的β转向比（AG）_（（ 15）。鉴于这种结构信息，设计了丝状矿化复合材料并通过固态NMR对其进行了表征。此外，重组蛋白是在大肠杆菌和转基因蚕中设计和生产的。这些重组蛋白的膜表现出高的钙结合活性和快速的矿化作用。

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  • 来源
  • 会议地点 Honolulu HI(US);Honolulu HI(US)
  • 作者

    Aya Nagano; Yu Suzuki; Yasumoto Nakazawa; J. T. Gerig; Tetsuo Asakura;

  • 作者单位

    Department of Biotechnology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, 184-8588 Japan;

    Department of Biotechnology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, 184-8588 Japan;

    Science Museum, Tokyo University of Agriculture and Technology,Koganei, Tokyo, 184-8588 Japan;

    Department of Chemistry, University of California,Santa Barbara, CA 93106 U.S.A.;

    Department of Biotechnology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, 184-8588 Japan;

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  • 正文语种 eng
  • 中图分类 聚合反应过程;
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