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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XX >Depth-resolved nanoscale nuclear architecture mapping for early prediction of cancer progression
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Depth-resolved nanoscale nuclear architecture mapping for early prediction of cancer progression

机译：深度解析的纳米级核结构图谱，可早期预测癌症进展

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摘要

Effective management of patients who are at risk of developing invasive cancer is a primary challenge in early cancer detection. Techniques that can help establish clear-cut protocols for successful triaging of at-risk patients have the potential of providing critical help in improving patient care while simultaneously reducing patient cost. We have developed such a technique for early prediction of cancer progression that uses unstained tissue sections to provide depth-resolved nanoscale nuclear architecture mapping (nanoNAM) of heterogeneity in optical density alterations manifested in precancerous lesions during cancer progression. We present nanoNAM and its application to predicting cancer progression in a well-established mouse model of spontaneous carcinogenesis: Apc~(Min/+) mice.
机译：对有发生浸润性癌症风险的患者进行有效管理是早期癌症检测的主要挑战。可以帮助建立明确协议以成功分流高危患者的技术，有可能在改善患者护理水平的同时提供关键帮助，同时降低患者成本。我们已经开发出了一种用于癌症进展的早期预测的技术，该技术使用未染色的组织切片来提供深度分辨的纳米级核结构图（nanoNAM），其在癌进展过程中在癌前病变中表现出的光密度改变中具有异质性。我们介绍了nanoNAM及其在预测自发癌变的成熟小鼠模型中的癌症进展中的应用：Apc〜（Min / +）小鼠。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Shikhar Uttam; Hoa V. Pham; Justin LaFace; Douglas J. Hartman; Yang Liu;

  • 作者单位

    Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA;

    Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA;

    Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA;

    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;

    Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA,University of Pittsburgh Cancer Institute, Pittsburgh, PA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Optical coherence tomography; nanoscale; phase; cancer;

    机译：光学相干断层扫描；纳米级相;癌症;

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