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首页> 外文会议>Optical interactions with tissue and cells XXVI >Improvement of thermal effects to rabbit atherosclerotic aortas by macro pulse irradiation of a quantum cascade laser in the 5.7 μm wavelength range
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Improvement of thermal effects to rabbit atherosclerotic aortas by macro pulse irradiation of a quantum cascade laser in the 5.7 μm wavelength range

机译：通过在5.7μm波长范围内的量子级联激光的大脉冲辐照改善对兔动脉粥样硬化主动脉的热效应

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摘要

Atherosclerotic plaques mainly consist of cholesteryl esters. Cholesteryl esters have an absorption peak at the wavelength of 5.75 μm originated from C=O stretching vibration mode of ester bond. Our group achieved making cutting difference between atherosclerotic lesions and normal vessels using a quantum cascade laser (QCL) in the 5.7 μm wavelength range. QCLs are relatively new types of semiconductor lasers that can emit mid-infrared range. They are sufficiently compact and have recently achieved their high-power emission. However, large thermal damage was observed because the QCL worked as a quasi-continuous wave laser due to its short pulse interval. To realize less-invasive ablation by the QCL, reducing thermal effects to normal vessels is needed. In this study, we tried improving the thermal effects by changing the pulse structure. First, irradiation effects to rabbit atherosclerotic aortas by macro pulse irradiation (irradiation of pulses at intervals) and conventional continuous pulse irradiation were compared. The macro pulse width and the macro pulse interval were set to 0.54 and 12 ms, respectively, because the thermal relaxation time of rabbit normal and atherosclerotic aortas in the oscillation wavelength was 0.54-12 ms. As a result, ablation depth became longer and coagulation width became shorter by the macro pulse irradiation. In addition, cutting difference between rabbit normal and atherosclerotic aortas was observed by the macro pulse irradiation. Therefore, the macro pulse irradiation achieved the improvement of thermal effects by the QCL in the 5.7 μm wavelength range. The QCL has the potential of realizing less-invasive laser angioplasty.
机译：动脉粥样硬化斑块主要由胆固醇酯组成。胆固醇酯在5.75μm的波长处具有吸收峰，该吸收峰源自酯键的C ＝ O拉伸振动模式。我们的小组使用波长为5.7μm的量子级联激光（QCL）实现了动脉粥样硬化病变和正常血管之间的切割差异。 QCL是可以发射中红外范围的相对新型的半导体激光器。它们足够紧凑，并且最近实现了高功率发射。但是，由于QCL由于其脉冲间隔短而可以用作准连续波激光器，因此观察到较大的热损伤。为了通过QCL实现侵入性较小的消融，需要减少对正常血管的热效应。在这项研究中，我们试图通过改变脉冲结构来改善热效应。首先，比较了通过大脉冲照射（间隔照射）和常规连续脉冲照射对兔动脉粥样硬化主动脉的照射效果。宏脉冲宽度和宏脉冲间隔分别设置为0.54和12 ms，因为兔子正常和动脉粥样硬化主动脉在振荡波长下的热弛豫时间为0.54-12 ms。结果，通过大脉冲照射，消融深度变长，凝结宽度变短。另外，通过大脉冲照射观察到兔正常和动脉粥样硬化主动脉之间的切割差异。因此，通过在5.7μm波长范围内的QCL，大脉冲照射实现了热效应的改善。 QCL具有实现微创激光血管成形术的潜力。

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  • 来源
    《Optical interactions with tissue and cells XXVI》|2015年|93210B.1-93210B.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Keisuke Hashimura; Katsunori Ishii; Kunio Awazu;

  • 作者单位

    Medical Beam Physics Laboratory, Graduate School of Engineering, Osaka University, Bldg.Al, 2-1 Yamadaoka, Suita, Osaka, Japan 565-0871,Research Fellow of Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda, Tokyo, Japan 102-0083;

    Medical Beam Physics Laboratory, Graduate School of Engineering, Osaka University, Bldg.Al, 2-1 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Medical Beam Physics Laboratory, Graduate School of Engineering, Osaka University, Bldg.Al, 2-1 Yamadaoka, Suita, Osaka, Japan 565-0871,Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, Japan 565-0871,The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan 565-0871;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    quantum cascade laser; atherosclerosis; laser angioplasty; less-invasive treatment; macro pulse irradiation;

    机译：量子级联激光器动脉粥样硬化激光血管成形术微创治疗；大脉冲照射;

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