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首页> 外文会议>Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXI >A real-time treatment guidance system for Pleural PDT
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A real-time treatment guidance system for Pleural PDT

机译：胸膜PDT的实时治疗指导系统

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摘要

Intrapleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for mesothelioma. In the current intrapleural PDT protocol, a moving fiber-based point source is used to deliver the light and the light dose are monitored by 7 detectors placed in the pleural cavity. To improve the delivery of light dose uniformity, an infrared (IR) camera system is used to track the motion of the light sources. A treatment planning system uses feedback from the detectors as well as the IR camera to update light fluence distribution in real-time, which is used to guide the light source motion for uniform light dose distribution. We have reported previously the success of using IR camera to passively monitor the light fluence rate distribution. In this study, the real-time feedback has been implemented in the current system prototype, by transferring data from the IR camera to a computer at a rate of 20 Hz, and by calculation/displaying using Matlab. A dual-correction method is used in the feedback system, so that fluence calculation can match detector readings. Preliminary data from a phantom showed superior light uniformity using this method. Light fluence uniformity from patient treatments is also shown using the correction method dose model.
机译：胸膜内光动力疗法（PDT）已被用作间皮瘤的保肺手术的辅助治疗方法。在当前的胸膜内PDT协议中，基于移动纤维的点光源用于传递光，并且通过放置在胸膜腔中的7个检测器监视光剂量。为了改善光剂量均匀性的传递，使用了红外（IR）摄像头系统来跟踪光源的运动。一个治疗计划系统使用来自检测器以及红外摄像机的反馈来实时更新光通量分布，该分布用于指导光源运动以实现均匀的光剂量分布。我们以前曾报道过使用红外摄像机被动监视光通量率分布的成功。在这项研究中，实时反馈已在当前系统原型中实现，方法是将红外摄像机的数据以20 Hz的速率传输到计算机，并使用Matlab进行计算/显示。反馈系统中使用了双重校正方法，因此注量计算可以匹配检测器读数。使用该方法，来自幻像的初步数据显示出优异的光均匀性。还使用校正方法剂量模型显示了来自患者治疗的光通量均匀性。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Timothy C. Zhu; Xing Liang; Julia Sandell; Jarod C. Finlay; Andreea Dimofte; CarmenRodriguez; Keith Cengel; Joseph Friedberg; Stephen M Hahn; Eli Glatstein;

  • 作者单位

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    @;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

    Department of Radiation Oncology, University of Pennsylvania, 3400 Civic Center Boulevard,Philadelphia, PA, USA 19104;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光、激光生物医学;
  • 关键词

    IR navigation; photodynamic therapy; pleural PDT;

    机译：红外导航；光动力疗法；胸膜PDT;

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