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Identification and quantitative evaluation of the fiber structure in the pathological tissue using Mueller matrix microscope

机译：用Mueller矩阵显微镜鉴定和定量评估病理组织中的纤维结构

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摘要

Fiber structure changes in the various pathological processes, such as the increase of fibrosis in liver diseases, the derangement of fiber in cervical cancer and so on. Currently, clinical pathologic diagnosis is regarded as the golden criterion, but different doctors with discrepancy in knowledge and experience may obtain different conclusions. Up to a point, quantitative evaluation of the fiber structure in the pathological tissue can be of great service to quantitative diagnosis. Mueller matrix measurement is capable of probing comprehensive microstructural information of samples and different wavelength of lights can provide more information. In this paper, we use a Mueller matrix microscope with light sources in six different wavelength. We use unstained, dewaxing liver tissue slices in four stages and the pathological biopsy of the filtration channels from rabbit eyes as samples. We apply the Mueller matrix polar decomposition (MMPD) parameter S which corresponds to retardance to liver slices. The mean value of abnormal region get bigger when the level of fibrosis get higher and light in short wavelength is more sensitive to the microstructure of fiber. On the other hand, we use the Mueller matrix transformation (MMT) parameter 0 which is associated to the angel of fast axis in the analysis of the slices of the filtration channels from rabbit eyes. The value of kurtosis and the value of skewness shows big difference between new born region and normal region and can reveal the arrangement of fiber. These results indicate that the Mueller matrix microscope has great potential in auxiliary diagnosis.
机译：纤维结构在各种病理过程中都会发生变化，例如肝脏疾病中纤维化的增加，子宫颈癌中纤维的排列等等。目前，临床病理诊断被认为是黄金标准，但是不同知识和经验的医生可能会得出不同的结论。到目前为止，对病理组织中纤维结构的定量评估对于定量诊断非常有用。 Mueller矩阵测量能够探测样品的全面微观结构信息，并且不同波长的光可以提供更多信息。在本文中，我们使用带有六种不同波长的光源的Mueller矩阵显微镜。我们使用四个阶段的未染色，脱蜡的肝组织切片和兔眼滤过通道的病理活检作为样本。我们应用了穆勒矩阵极坐标分解（MMPD）参数S，它对应于肝切片的延迟。纤维化程度越高，短波长的光对纤维的微观结构越敏感，异常区域的平均值越大。另一方面，在分析兔眼滤过通道的切片时，我们使用与快轴角度相关的Mueller矩阵变换（MMT）参数0。峰度值和偏度值在新生区域和正常区域之间显示出较大差异，并且可以揭示纤维的排列。这些结果表明，Mueller矩阵显微镜在辅助诊断中具有巨大的潜力。

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  • 来源
    《Optical tomography and spectroscopy of tissue XII》|2017年|1005926.1-1005926.9|共9页
  • 会议地点 San Francisco(US)
  • 作者

    Jialing Zhou; Honghui He; Ye Wang; Hui Ma;

  • 作者单位

    Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China,Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China;

    Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;

    Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China,Department of Physics, Tsinghua University, Beijing 100084, China;

    Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China,Department of Physics, Tsinghua University, Beijing 100084, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Polarization; Mueller matrix; microscope; fiber structure; liver fibrosis; glaucoma;

    机译：偏振;穆勒矩阵;显微镜;纤维结构肝纤维化青光眼;

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